TY - JOUR
T1 - Successful Bone Marrow Transplantation with Intensive Post-transplant Intrathecal Chemotherapy for CNS Relapsed AML in 2 Infants
AU - Andolina, Jeffrey R.
AU - Fries, Carol
AU - Boulware, Renee
AU - Vargas, Alyssa
AU - Fraint, Ellen
AU - Barth, Matthew
AU - Ambrusko, Steven
AU - Comito, Melanie
AU - Monteleone, Philip
N1 - Publisher Copyright:
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Background: Infant acute myeloid leukemia is a rare but aggressive form of leukemia. Observation: We report 2 children who presented with hyperleukocytosis, subsequently diagnosed with infant acute myeloid leukemia, and both developed isolated central nervous system relapse while on chemotherapy. Both infants underwent successful bone marrow transplantation with myeloablative conditioning (thiotepa, busulfan, and cyclophosphamide) without radiation, followed by 12 empiric post-transplant lumbar punctures with intrathecal cytarabine. Both patients tolerated these therapies well, and are without infections, chronic graft-versus-host disease, or any post-transplant sequelae. Conclusion: Nonradiation-based conditioning followed by empiric central nervous system-directed intrathecal chemotherapy may be considered for high-risk infants with leukemia.
AB - Background: Infant acute myeloid leukemia is a rare but aggressive form of leukemia. Observation: We report 2 children who presented with hyperleukocytosis, subsequently diagnosed with infant acute myeloid leukemia, and both developed isolated central nervous system relapse while on chemotherapy. Both infants underwent successful bone marrow transplantation with myeloablative conditioning (thiotepa, busulfan, and cyclophosphamide) without radiation, followed by 12 empiric post-transplant lumbar punctures with intrathecal cytarabine. Both patients tolerated these therapies well, and are without infections, chronic graft-versus-host disease, or any post-transplant sequelae. Conclusion: Nonradiation-based conditioning followed by empiric central nervous system-directed intrathecal chemotherapy may be considered for high-risk infants with leukemia.
KW - Acute myeloid leukemia
KW - Bone marrow transplantation
KW - CNS
KW - Infant
KW - Pediatric
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U2 - 10.1097/MPH.0000000000002151
DO - 10.1097/MPH.0000000000002151
M3 - Article
C2 - 33843815
AN - SCOPUS:85123282088
SN - 1077-4114
VL - 44
SP - E264-E267
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 1
ER -