Successful Bone Marrow Transplantation of an Adolescent Young Adult Female with Pregnancy-associated Aplastic Anemia

Hisham Abdel-Azim, Baro Jovi-Usude, Chelsea Balian, Ami J. Shah, Shinyi Tang, Arpan Sinha, Neena Kapoor, Kris M. Mahadeo

Research output: Contribution to journalArticle

Abstract

Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA.

Original languageEnglish (US)
Pages (from-to)319-321
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume37
Issue number4
DOIs
Publication statusPublished - Dec 1 2015

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Keywords

  • BMT
  • aplastic anemia
  • pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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