Successful Bone Marrow Transplantation of an Adolescent Young Adult Female with Pregnancy-associated Aplastic Anemia

Hisham Abdel-Azim; Baro Jovi-Usude; Chelsea Balian; Ami J. Shah; Shinyi Tang; Arpan Sinha; Neena Kapoor; Kris M. Mahadeo

doi:10.1097/MPH.0000000000000314

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female with Pregnancy-associated Aplastic Anemia

Hisham Abdel-Azim, Baro Jovi-Usude, Chelsea Balian, Ami J. Shah, Shinyi Tang, Arpan Sinha, Neena Kapoor, Kris M. Mahadeo

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA.

Original language	English (US)
Pages (from-to)	319-321
Number of pages	3
Journal	Journal of Pediatric Hematology/Oncology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1097/MPH.0000000000000314
State	Published - Dec 1 2015

Keywords

BMT
aplastic anemia
pregnancy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000000314

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title = "Successful Bone Marrow Transplantation of an Adolescent Young Adult Female with Pregnancy-associated Aplastic Anemia",

abstract = "Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA.",

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AU - Abdel-Azim, Hisham

AU - Jovi-Usude, Baro

AU - Balian, Chelsea

AU - Shah, Ami J.

AU - Tang, Shinyi

AU - Sinha, Arpan

AU - Kapoor, Neena

AU - Mahadeo, Kris M.

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AB - Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA.

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Successful Bone Marrow Transplantation of an Adolescent Young Adult Female with Pregnancy-associated Aplastic Anemia

Abstract

Keywords

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