Successful Bone-Marrow Transplantation in a Lymphopenic Immunologic Deficiency Syndrome

A. Rubinstein, B. Speck, M. Jeannet

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A 12-year-old boy with lymphopenic immunologic deficiency syndrome (common variable type) was treated with an infusion of bone-marrow cells from a 10-year-old HL-A identical brother. Despite the HL-A identity and a negative mixed lymphocyte culture, a severe graft-versus-host reaction developed from which he recovered, except for persisting hepatitis. The transplant resulted in red-cell chimerism and in an immunologic reconstitution that was almost complete but of an unusual pattern. IgM and IgG concentration increased and exceeded those of normal adults.

Original languageEnglish (US)
Pages (from-to)1399-1402
Number of pages4
JournalNew England Journal of Medicine
Issue number25
StatePublished - Dec 16 1971
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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