Successful adherence to observed prophylaxis and treatment of tuberculosis among drug users in a methadone program

Marc N. Gourevitch, William Wasserman, Maria S. Panero, Peter A. Selwyn

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Incomplete antituberculous chemoprophylaxis and treatment are major causes of the resurgence of tuberculosis, often drug-resistant, among drug users. We offered directly observed antituberculous chemoprophylaxis (n = 102) or treatment (n = 12) to eligible methadone maintenance treatment patients. Methadone dosing was not contingent upon ingestion of antituberculous medication(s). No material incentives were provided. Ninety (88%) prophylaxis and 9 (75%) treatment patients were administered ≥ 5 weekly doses of antituberculous medications during ≥ 80% of 4740 patient-weeks. The majority of patients were HIV-seropositive. Active substance abuse was not associated with diminished adherence. Over 80% of patients completed or were still receiving therapy at the end of the study. Adherence to and completion of directly observed antituberculous therapy can thus be attained by drug users in treatment, despite ongoing drug misuse. Substance abuse treatment programs provide opportunities for enhanced compliance, and should thus be viewed as critical components of strategies to address the tuberculosis epidemic in drug users.

Original languageEnglish (US)
Pages (from-to)93-104
Number of pages12
JournalJournal of Addictive Diseases
Volume15
Issue number1
DOIs
StatePublished - 1996

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Methadone
Drug Users
Tuberculosis
Chemoprevention
Therapeutics
Substance-Related Disorders
Directly Observed Therapy
Multidrug-Resistant Tuberculosis
Compliance
Motivation
Eating
HIV
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Successful adherence to observed prophylaxis and treatment of tuberculosis among drug users in a methadone program. / Gourevitch, Marc N.; Wasserman, William; Panero, Maria S.; Selwyn, Peter A.

In: Journal of Addictive Diseases, Vol. 15, No. 1, 1996, p. 93-104.

Research output: Contribution to journalArticle

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