Subthalamic nucleus: A new anticonvulsant site in the brain

Jana Velíšková, Libor Velšek, Solomon L. Moshé

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Several brain sites are important for seizure control, including the area tempestas, superior colliculus, thalamus and substantia nigra. These sites are especially sensitive to changes in GABAergic transmission achieved by localized infusions of GABAergic agents. We investigated the effects of the GABA(A) receptor agonist muscimol (100 ng in a volume of 0.25 μl) microinfused into the subthalamic nucleus (STN) in the flurothyl seizure model in male adult rats. Both bilateral symmetrical and unilateral STN infusions of muscimol had a significant anticonvulsant effect against flurothyl-induced clonic seizures. Our data suggest that the STN is a part of the network responsible for the control of clonic seizures.

Original languageEnglish (US)
Pages (from-to)1786-1788
Number of pages3
JournalNeuroReport
Volume7
Issue number11
DOIs
StatePublished - Jan 1 1996

Keywords

  • GABA(A) receptors
  • flurothyl
  • infusions
  • muscimol
  • seizures

ASJC Scopus subject areas

  • Neuroscience(all)

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