Subthalamic deep brain stimulation and impulse control in Parkinson's disease

T. D. Hälbig, W. Tse, P. G. Frisina, B. R. Baker, Eric Hollander, H. Shapiro, M. Tagliati, W. C. Koller, C. W. Olanow

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Background and purpose: Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson's disease (PD). The purpose of this study was to assess various measures of impulse control in PD patients with STN DBS in comparison to patients receiving medical therapy. Methods: In a cross-sectional evaluation, 53 consecutively eligible patients were assessed for impulsivity with the Barratt Impulsiveness Scale, for impulse control disorders (ICDs) using the Minnesota Impulsive Disorders Interview, and for obsessive-compulsive symptoms using the Maudsley Obsessional-Compulsive Inventory. Results: Independent samples t-tests revealed that compulsivity scores were not different between DBS patients and patients without DBS. However, impulsivity scores were significantly higher in DBS patients. Additionally, ICDs were observed in 3 of 16 (19%) DBS patients and in 3 of 37 (8%) medically treated patients. No association was found between the use of dopamine agonists and impulsivity in DBS patients. Conclusions: Our data suggest that screening for impulsivity and ICDs should be performed prior to DBS, and that patients should be monitored for these problems during follow-up. Prospective trials are needed to confirm the findings of this exploratory study and to elucidate the reasons of a possible induction of impulsivity by STN DBS.

Original languageEnglish (US)
Pages (from-to)493-497
Number of pages5
JournalEuropean Journal of Neurology
Volume16
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Deep Brain Stimulation
Parkinson Disease
Impulsive Behavior
Disruptive, Impulse Control, and Conduct Disorders
Subthalamic Nucleus
Obsessive-Compulsive Disorder
Dopamine Agonists
Interviews

Keywords

  • Deep brain stimulation
  • Impulsivity
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Hälbig, T. D., Tse, W., Frisina, P. G., Baker, B. R., Hollander, E., Shapiro, H., ... Olanow, C. W. (2009). Subthalamic deep brain stimulation and impulse control in Parkinson's disease. European Journal of Neurology, 16(4), 493-497. https://doi.org/10.1111/j.1468-1331.2008.02509.x

Subthalamic deep brain stimulation and impulse control in Parkinson's disease. / Hälbig, T. D.; Tse, W.; Frisina, P. G.; Baker, B. R.; Hollander, Eric; Shapiro, H.; Tagliati, M.; Koller, W. C.; Olanow, C. W.

In: European Journal of Neurology, Vol. 16, No. 4, 04.2009, p. 493-497.

Research output: Contribution to journalArticle

Hälbig, TD, Tse, W, Frisina, PG, Baker, BR, Hollander, E, Shapiro, H, Tagliati, M, Koller, WC & Olanow, CW 2009, 'Subthalamic deep brain stimulation and impulse control in Parkinson's disease', European Journal of Neurology, vol. 16, no. 4, pp. 493-497. https://doi.org/10.1111/j.1468-1331.2008.02509.x
Hälbig, T. D. ; Tse, W. ; Frisina, P. G. ; Baker, B. R. ; Hollander, Eric ; Shapiro, H. ; Tagliati, M. ; Koller, W. C. ; Olanow, C. W. / Subthalamic deep brain stimulation and impulse control in Parkinson's disease. In: European Journal of Neurology. 2009 ; Vol. 16, No. 4. pp. 493-497.
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