Substrate specificity: PI(3)Kγ has it both ways

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)Kγ. Phosphorylation of tropomyosin is required for β-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.

Original languageEnglish (US)
Pages (from-to)773-774
Number of pages2
JournalNature Cell Biology
Volume7
Issue number8
DOIs
StatePublished - Aug 2005

Fingerprint

Tropomyosin
1-Phosphatidylinositol 4-Kinase
Substrate Specificity
Clathrin
Endocytosis
Adrenergic Receptors
Protein Kinases
Phosphotransferases
Phosphorylation
Lipids
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Substrate specificity : PI(3)Kγ has it both ways. / Backer, Jonathan M.

In: Nature Cell Biology, Vol. 7, No. 8, 08.2005, p. 773-774.

Research output: Contribution to journalArticle

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