Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration

S. Goto, S. Hirano, S. Matsumoto

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

A topographical immunocytochemical analysis was performed on the substantia nigra from patients with idiopathic Parkinson's disease and striatonigral degeneration. Antibodies to tyrosine hydroxylase, a marker for nigrostriatal dopaminergic neurons, and to calcineurin, a marker for striatonigral projection fibers, were used in this study. There was a marked depletion of dopaminergic neurons in the substantia nigra of parkinsonian patients compared with control subjects, the reduction being greater in the lateral portion than in the medial portion (p < 0.001). Calcineurin immunoreactivity was densely distributed throughout the substantia nigra of patients with Parkinson's disease and control subjects. The numbers of dopaminergic neurons and of calcineurin-immunoreactive fibers were markedly reduced in the lateral portion of the substantia nigra in all patients with striatonigral degeneration. Our results suggest that many symptoms of these two diseases may be due to disruption of the functions of the putamen and the lateral portion of the substantia nigra, which have dense reciprocal connections as part of the dopamine-related nigrostriatal loop.

Original languageEnglish (US)
Pages (from-to)766-770
Number of pages5
JournalAnnals of Neurology
Volume26
Issue number6
DOIs
StatePublished - 1989

Fingerprint

Striatonigral Degeneration
Substantia Nigra
Parkinson Disease
Calcineurin
Dopaminergic Neurons
Putamen
Tyrosine 3-Monooxygenase
Dopamine
Antibodies

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration. / Goto, S.; Hirano, S.; Matsumoto, S.

In: Annals of Neurology, Vol. 26, No. 6, 1989, p. 766-770.

Research output: Contribution to journalArticle

@article{fc964bfd86b64d25a2b3373f7c997392,
title = "Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration",
abstract = "A topographical immunocytochemical analysis was performed on the substantia nigra from patients with idiopathic Parkinson's disease and striatonigral degeneration. Antibodies to tyrosine hydroxylase, a marker for nigrostriatal dopaminergic neurons, and to calcineurin, a marker for striatonigral projection fibers, were used in this study. There was a marked depletion of dopaminergic neurons in the substantia nigra of parkinsonian patients compared with control subjects, the reduction being greater in the lateral portion than in the medial portion (p < 0.001). Calcineurin immunoreactivity was densely distributed throughout the substantia nigra of patients with Parkinson's disease and control subjects. The numbers of dopaminergic neurons and of calcineurin-immunoreactive fibers were markedly reduced in the lateral portion of the substantia nigra in all patients with striatonigral degeneration. Our results suggest that many symptoms of these two diseases may be due to disruption of the functions of the putamen and the lateral portion of the substantia nigra, which have dense reciprocal connections as part of the dopamine-related nigrostriatal loop.",
author = "S. Goto and S. Hirano and S. Matsumoto",
year = "1989",
doi = "10.1002/ana.410260613",
language = "English (US)",
volume = "26",
pages = "766--770",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration

AU - Goto, S.

AU - Hirano, S.

AU - Matsumoto, S.

PY - 1989

Y1 - 1989

N2 - A topographical immunocytochemical analysis was performed on the substantia nigra from patients with idiopathic Parkinson's disease and striatonigral degeneration. Antibodies to tyrosine hydroxylase, a marker for nigrostriatal dopaminergic neurons, and to calcineurin, a marker for striatonigral projection fibers, were used in this study. There was a marked depletion of dopaminergic neurons in the substantia nigra of parkinsonian patients compared with control subjects, the reduction being greater in the lateral portion than in the medial portion (p < 0.001). Calcineurin immunoreactivity was densely distributed throughout the substantia nigra of patients with Parkinson's disease and control subjects. The numbers of dopaminergic neurons and of calcineurin-immunoreactive fibers were markedly reduced in the lateral portion of the substantia nigra in all patients with striatonigral degeneration. Our results suggest that many symptoms of these two diseases may be due to disruption of the functions of the putamen and the lateral portion of the substantia nigra, which have dense reciprocal connections as part of the dopamine-related nigrostriatal loop.

AB - A topographical immunocytochemical analysis was performed on the substantia nigra from patients with idiopathic Parkinson's disease and striatonigral degeneration. Antibodies to tyrosine hydroxylase, a marker for nigrostriatal dopaminergic neurons, and to calcineurin, a marker for striatonigral projection fibers, were used in this study. There was a marked depletion of dopaminergic neurons in the substantia nigra of parkinsonian patients compared with control subjects, the reduction being greater in the lateral portion than in the medial portion (p < 0.001). Calcineurin immunoreactivity was densely distributed throughout the substantia nigra of patients with Parkinson's disease and control subjects. The numbers of dopaminergic neurons and of calcineurin-immunoreactive fibers were markedly reduced in the lateral portion of the substantia nigra in all patients with striatonigral degeneration. Our results suggest that many symptoms of these two diseases may be due to disruption of the functions of the putamen and the lateral portion of the substantia nigra, which have dense reciprocal connections as part of the dopamine-related nigrostriatal loop.

UR - http://www.scopus.com/inward/record.url?scp=0024835910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024835910&partnerID=8YFLogxK

U2 - 10.1002/ana.410260613

DO - 10.1002/ana.410260613

M3 - Article

C2 - 2557795

AN - SCOPUS:0024835910

VL - 26

SP - 766

EP - 770

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 6

ER -