TY - JOUR
T1 - Subclinical hypothyroidism and cardiovascular risk
T2 - Recommendations for treatment
AU - Weiss, Irene A.
AU - Bloomgarden, Noah
AU - Frishman, William H.
PY - 2011/11
Y1 - 2011/11
N2 - The definition of subclinical hypothyroidism (SCH) is solely biochemical: a serum free T4 level within the reference range in the presence of an elevated serum thyroid-stimulating hormone (TSH) level. While overt hypothyroidism is associated with an increased cardiovascular disease risk, SCH, the mildest form of hypothyroidism, may also be associated with an increased cardiovascular disease risk, but to a lesser degree. Recent evidence points to a significant trend toward an increase in cardiovascular risk at higher TSH levels, with TSH levels ≥10 mIU/L associated with increased cardiovascular morbidity and mortality. It is generally recommended to treat with thyroid hormone those individuals with SCH and TSH values ≥10 mIU/L. Treatment of patients with SCH and TSH values <10 is controversial but may be considered in selected patients.
AB - The definition of subclinical hypothyroidism (SCH) is solely biochemical: a serum free T4 level within the reference range in the presence of an elevated serum thyroid-stimulating hormone (TSH) level. While overt hypothyroidism is associated with an increased cardiovascular disease risk, SCH, the mildest form of hypothyroidism, may also be associated with an increased cardiovascular disease risk, but to a lesser degree. Recent evidence points to a significant trend toward an increase in cardiovascular risk at higher TSH levels, with TSH levels ≥10 mIU/L associated with increased cardiovascular morbidity and mortality. It is generally recommended to treat with thyroid hormone those individuals with SCH and TSH values ≥10 mIU/L. Treatment of patients with SCH and TSH values <10 is controversial but may be considered in selected patients.
KW - cardiovascular complications
KW - subclinical hypothyroidism
KW - thyroid replacement
KW - thyroid stimulating hormone
UR - http://www.scopus.com/inward/record.url?scp=80054046945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054046945&partnerID=8YFLogxK
U2 - 10.1097/CRD.0b013e318227df87
DO - 10.1097/CRD.0b013e318227df87
M3 - Review article
C2 - 21983317
AN - SCOPUS:80054046945
SN - 1061-5377
VL - 19
SP - 291
EP - 299
JO - Cardiology in review
JF - Cardiology in review
IS - 6
ER -