Subcellular compartmentalization of insulin signaling processes and GLUT4 trafficking events

Robert T. Watson, Alan R. Saltiel, Jeffrey E. Pessin, Makoto Kanzaki

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Skeletal muscle and adipose tissue are the major sites of postprandial glucose disposal. The insulin-regulated transport of glucose into these tissues is a multi-step process that begins with the binding of insulin to its cell surface receptor. Once activated, the insulin receptor generates multiple intracellular signaling cascades, some of which induce the rapid redistribution of the GLUT4 facilitative glucose transporter from intracellular compartments to the plasma membrane. Although probably best known for its role in glucose homeostasis, insulin regulates a variety of metabolic, mitogenic, and anti-apoptotic processes in specific tissues. Moreover, in addition to insulin several other hormones and growth factors can also activate signaling targets that function downstream of the insulin receptor. For example, phosphatidylinositol-3′-kinase (PI3K), a key enzyme in the signaling pathway leading to insulin-stimulated glucose uptake, can be activated by many extracellular signals. However, only insulin and highly related hormones such as IGF-I efficiently stimulate acute glucose transport. These observations suggest that cellular mechanisms have evolved for maintaining specificity among signaling pathways mediated by various hormones and growth factors. Elucidating the underlying mechanisms for this specificity is a current challenge engaging the attention of many researchers, and will require a thorough understanding of the signaling pathway responsible for each cellular response. To this end, recent work suggests that the coordination of multiple pathways occurs in part through the intracellular compartmentalization of key signaling molecules. Indeed, subcellular compartmentalization plays a critical role in maintaining the specificity of insulin signaling and the fidelity of GLUT4 vesicle trafficking.

Original languageEnglish (US)
Title of host publicationMechanisms of Insulin Action: Medical Intelligence Unit
PublisherSpringer New York
Pages33-51
Number of pages19
ISBN (Print)9780387722030
DOIs
StatePublished - 2007
Externally publishedYes

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Insulin
Glucose
Insulin Receptor
Hormones
Intercellular Signaling Peptides and Proteins
Phosphatidylinositol 3-Kinase
Facilitative Glucose Transport Proteins
Cell Surface Receptors
Insulin-Like Growth Factor I
Adipose Tissue
Skeletal Muscle
Homeostasis
Research Personnel
Cell Membrane
Muscles
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Watson, R. T., Saltiel, A. R., Pessin, J. E., & Kanzaki, M. (2007). Subcellular compartmentalization of insulin signaling processes and GLUT4 trafficking events. In Mechanisms of Insulin Action: Medical Intelligence Unit (pp. 33-51). Springer New York. https://doi.org/10.1007/978-0-387-72204-7_2

Subcellular compartmentalization of insulin signaling processes and GLUT4 trafficking events. / Watson, Robert T.; Saltiel, Alan R.; Pessin, Jeffrey E.; Kanzaki, Makoto.

Mechanisms of Insulin Action: Medical Intelligence Unit. Springer New York, 2007. p. 33-51.

Research output: Chapter in Book/Report/Conference proceedingChapter

Watson, RT, Saltiel, AR, Pessin, JE & Kanzaki, M 2007, Subcellular compartmentalization of insulin signaling processes and GLUT4 trafficking events. in Mechanisms of Insulin Action: Medical Intelligence Unit. Springer New York, pp. 33-51. https://doi.org/10.1007/978-0-387-72204-7_2
Watson RT, Saltiel AR, Pessin JE, Kanzaki M. Subcellular compartmentalization of insulin signaling processes and GLUT4 trafficking events. In Mechanisms of Insulin Action: Medical Intelligence Unit. Springer New York. 2007. p. 33-51 https://doi.org/10.1007/978-0-387-72204-7_2
Watson, Robert T. ; Saltiel, Alan R. ; Pessin, Jeffrey E. ; Kanzaki, Makoto. / Subcellular compartmentalization of insulin signaling processes and GLUT4 trafficking events. Mechanisms of Insulin Action: Medical Intelligence Unit. Springer New York, 2007. pp. 33-51
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