Study design and sample size considerations for half-life studies

M. Y. Kim, N. Dubin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Most studies on the half-lives of environmental contaminants have been based on small sample sizes and a limited number of repeated measurements. In this paper, we address issues of study design and sample size for half-life studies. Useful guidelines are provided for choosing the number of repeats and the optimal time interval between repeats for estimating an individual's half-life with a given level of precision, while minimizing the cost of the study. In addition, sample size and power considerations for studies comparing two population half-lives are investigated. An example is presented using data from a study on polychlorinated biphenyls and breast cancer.

Original languageEnglish (US)
Pages (from-to)423-429
Number of pages7
JournalArchives of Environmental Contamination and Toxicology
Issue number3
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis


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