Most studies on the half-lives of environmental contaminants have been based on small sample sizes and a limited number of repeated measurements. In this paper, we address issues of study design and sample size for half-life studies. Useful guidelines are provided for choosing the number of repeats and the optimal time interval between repeats for estimating an individual's half-life with a given level of precision, while minimizing the cost of the study. In addition, sample size and power considerations for studies comparing two population half-lives are investigated. An example is presented using data from a study on polychlorinated biphenyls and breast cancer.
|Original language||English (US)|
|Number of pages||7|
|Journal||Archives of Environmental Contamination and Toxicology|
|State||Published - Jan 1 1996|
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis