Studies with RP 56976 (taxotere): A semisynthetic analogue of taxol

Israel Ringel, Susan Band Horwitz

Research output: Contribution to journalArticle

685 Scopus citations

Abstract

RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, Promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells.Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells. [J Natl Cancer Inst 83:288-291, 1991].

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalJournal of the National Cancer Institute
Volume83
Issue number4
DOIs
StatePublished - Feb 20 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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