Studies with RP 56976 (taxotere): A semisynthetic analogue of taxol

Israel Ringel, Susan Band Horwitz

Research output: Contribution to journalArticle

681 Citations (Scopus)

Abstract

RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, Promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells.Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells. [J Natl Cancer Inst 83:288-291, 1991].

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalJournal of the National Cancer Institute
Volume83
Issue number4
DOIs
StatePublished - Feb 20 1991

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docetaxel
Paclitaxel
Polymerization
Analogue
Cell
Microtubules
Inhibitor
Replication
Cancer
Fold
Tubulin Modulators
Guanosine Triphosphate
Promoter
Bundle
Neoplasms
Drugs

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Cancer Research

Cite this

Studies with RP 56976 (taxotere) : A semisynthetic analogue of taxol. / Ringel, Israel; Band Horwitz, Susan.

In: Journal of the National Cancer Institute, Vol. 83, No. 4, 20.02.1991, p. 288-291.

Research output: Contribution to journalArticle

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