Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: Observation of the catalytic loop in the open conformation in the ligand-bound state

S. Parthasarathy, Hemalatha Balaram, P. Balaram, M. R.N. Murthy

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Structures of triosephosphate isomerase (TIM) from the malarial parasite P. falciparum (Pf) complexed to the substrate analogues 3-phosphoglycerate and glycerol-3-phosphate have been determined at 2.4 Å resolution. The catalytic loop of TIM adopts a novel 'loop-open' conformation in these complexes. These structures provide insight into the design of inhibitors specific for the malarial enzyme.

Original languageEnglish (US)
Pages (from-to)1992-2000
Number of pages9
JournalActa Crystallographica Section D: Biological Crystallography
Issue number12
Publication statusPublished - Dec 1 2002


ASJC Scopus subject areas

  • Structural Biology

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