Structures of triosephosphate isomerase (TIM) from the malarial parasite P. falciparum (Pf) complexed to the substrate analogues 3-phosphoglycerate and glycerol-3-phosphate have been determined at 2.4 Å resolution. The catalytic loop of TIM adopts a novel 'loop-open' conformation in these complexes. These structures provide insight into the design of inhibitors specific for the malarial enzyme.
|Original language||English (US)|
|Number of pages||9|
|Journal||Acta Crystallographica Section D: Biological Crystallography|
|Publication status||Published - Dec 1 2002|
ASJC Scopus subject areas
- Structural Biology