Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: Observation of the catalytic loop in the open conformation in the ligand-bound state

S. Parthasarathy; Hemalatha Balaram; P. Balaram; M. R.N. Murthy

doi:10.1107/S0907444902015433

Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: Observation of the catalytic loop in the open conformation in the ligand-bound state

S. Parthasarathy, Hemalatha Balaram, P. Balaram, M. R.N. Murthy

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Structures of triosephosphate isomerase (TIM) from the malarial parasite P. falciparum (Pf) complexed to the substrate analogues 3-phosphoglycerate and glycerol-3-phosphate have been determined at 2.4 Å resolution. The catalytic loop of TIM adopts a novel 'loop-open' conformation in these complexes. These structures provide insight into the design of inhibitors specific for the malarial enzyme.

Original language	English (US)
Pages (from-to)	1992-2000
Number of pages	9
Journal	Acta Crystallographica Section D: Biological Crystallography
Volume	58
Issue number	12
DOIs	https://doi.org/10.1107/S0907444902015433
State	Published - Dec 1 2002
Externally published	Yes

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Structural Biology

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Parthasarathy, S., Balaram, H., Balaram, P., & Murthy, M. R. N. (2002). Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: Observation of the catalytic loop in the open conformation in the ligand-bound state. Acta Crystallographica Section D: Biological Crystallography, 58(12), 1992-2000. https://doi.org/10.1107/S0907444902015433

Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: Observation of the catalytic loop in the open conformation in the ligand-bound state. / Parthasarathy, S.; Balaram, Hemalatha; Balaram, P. et al.
In: Acta Crystallographica Section D: Biological Crystallography, Vol. 58, No. 12, 01.12.2002, p. 1992-2000.

Research output: Contribution to journal › Article › peer-review

Parthasarathy, S, Balaram, H, Balaram, P & Murthy, MRN 2002, 'Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: Observation of the catalytic loop in the open conformation in the ligand-bound state', Acta Crystallographica Section D: Biological Crystallography, vol. 58, no. 12, pp. 1992-2000. https://doi.org/10.1107/S0907444902015433

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Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: Observation of the catalytic loop in the open conformation in the ligand-bound state

Abstract

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