Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis

Timothy L. Born; John S. Blanchard

doi:10.1016/S1367-5931(99)00016-2

Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis

Timothy L. Born, John S. Blanchard

Biochemistry

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Within the past 18 months work has continued on the structure and mechanisms of enzymes involved in the diaminopimelic acid/lysine biosynthetic pathway. A novel structure has been determined for a PLP-independent epimerase, and structures with bound substrates have been solved for two other enzymes. Additionally, new studies have appeared describing the chemical mechanisms of three enzymes in the pathway.

Original language	English (US)
Pages (from-to)	607-613
Number of pages	7
Journal	Current Opinion in Chemical Biology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1016/S1367-5931(99)00016-2
State	Published - Oct 1 1999

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1016/S1367-5931(99)00016-2

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abstract = "Within the past 18 months work has continued on the structure and mechanisms of enzymes involved in the diaminopimelic acid/lysine biosynthetic pathway. A novel structure has been determined for a PLP-independent epimerase, and structures with bound substrates have been solved for two other enzymes. Additionally, new studies have appeared describing the chemical mechanisms of three enzymes in the pathway.",

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AB - Within the past 18 months work has continued on the structure and mechanisms of enzymes involved in the diaminopimelic acid/lysine biosynthetic pathway. A novel structure has been determined for a PLP-independent epimerase, and structures with bound substrates have been solved for two other enzymes. Additionally, new studies have appeared describing the chemical mechanisms of three enzymes in the pathway.

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Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis

Abstract

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