Abstract
The first high-resolution crystal structure for liganded hemoglobin C, a mutant hemoglobin that forms crystals in red blood cells of individuals with CC and SC diseases, was obtained from a COHbC crystal grown in concentrated potassium phosphate buffer. The dynamic structure of the βEK6 side chain could potentially support a number of specific polar interactions that may contribute to enhanced nucleation kinetics for HbC relative to HbA.
Original language | English (US) |
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Pages (from-to) | 2038-2042 |
Number of pages | 5 |
Journal | Acta Crystallographica Section D: Biological Crystallography |
Volume | 58 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2002 |
ASJC Scopus subject areas
- Structural Biology