Structure of mutant human carbonmonoxyhemoglobin C (βE6K) at 2.0 Å resolution

John C. Dewan, Angela Feeling-Taylor, Yoram A. Puius, Larysa Patskovska, Yury Patskovsky, Ronald L. Nagel, Steven C. Almo, Rhoda Elison Hirsch

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5 Scopus citations

Abstract

The first high-resolution crystal structure for liganded hemoglobin C, a mutant hemoglobin that forms crystals in red blood cells of individuals with CC and SC diseases, was obtained from a COHbC crystal grown in concentrated potassium phosphate buffer. The dynamic structure of the βEK6 side chain could potentially support a number of specific polar interactions that may contribute to enhanced nucleation kinetics for HbC relative to HbA.

Original languageEnglish (US)
Pages (from-to)2038-2042
Number of pages5
JournalActa Crystallographica Section D: Biological Crystallography
Volume58
Issue number12
DOIs
StatePublished - Dec 1 2002

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ASJC Scopus subject areas

  • Structural Biology

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