STRUCTURE AND REACTIVITY IN HEMOGLOBIN: IMPLICATIONS OF RECENT PICOSECOND TRANSIENT RAMAN AND ABSORPTION STUDIES.

Joel M. Friedman, M. R. Ondrias, E. W. Findsen, S. R. Simon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Recent picosecond transient absorption studies show that the yield of geminate rebinding is sensitive to protein structure. Picosecond transient Raman studies reveal that over the time course of the geminate rebinding, the effective tertiary structure about the heme is not relaxing. The results of this study also imply strong coupling among the elements of tertiary structure that control both the frequency of iron-proximal histidine stretching motion and the ligand binding properties of the heme. These findings and conclusions are used to further develop a working model in which reactivity and structure about the heme are controlled by an effective tertiary structure associated with what Karplus and co-workers call an 'allosteric core' comprised of the heme, the proximal histidine (F-8), and a portion of the F-helix.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsM.J. Soileau
PublisherSPIE
Pages8-14
Number of pages7
Volume533
ISBN (Print)0892525681
StatePublished - 1985
Externally publishedYes

Fingerprint

histidine
Hemoglobin
hemoglobin
reactivity
helices
Stretching
Ligands
Iron
proteins
Proteins
iron
ligands

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Friedman, J. M., Ondrias, M. R., Findsen, E. W., & Simon, S. R. (1985). STRUCTURE AND REACTIVITY IN HEMOGLOBIN: IMPLICATIONS OF RECENT PICOSECOND TRANSIENT RAMAN AND ABSORPTION STUDIES. In M. J. Soileau (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 533, pp. 8-14). SPIE.

STRUCTURE AND REACTIVITY IN HEMOGLOBIN : IMPLICATIONS OF RECENT PICOSECOND TRANSIENT RAMAN AND ABSORPTION STUDIES. / Friedman, Joel M.; Ondrias, M. R.; Findsen, E. W.; Simon, S. R.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / M.J. Soileau. Vol. 533 SPIE, 1985. p. 8-14.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Friedman, JM, Ondrias, MR, Findsen, EW & Simon, SR 1985, STRUCTURE AND REACTIVITY IN HEMOGLOBIN: IMPLICATIONS OF RECENT PICOSECOND TRANSIENT RAMAN AND ABSORPTION STUDIES. in MJ Soileau (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 533, SPIE, pp. 8-14.
Friedman JM, Ondrias MR, Findsen EW, Simon SR. STRUCTURE AND REACTIVITY IN HEMOGLOBIN: IMPLICATIONS OF RECENT PICOSECOND TRANSIENT RAMAN AND ABSORPTION STUDIES. In Soileau MJ, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 533. SPIE. 1985. p. 8-14
Friedman, Joel M. ; Ondrias, M. R. ; Findsen, E. W. ; Simon, S. R. / STRUCTURE AND REACTIVITY IN HEMOGLOBIN : IMPLICATIONS OF RECENT PICOSECOND TRANSIENT RAMAN AND ABSORPTION STUDIES. Proceedings of SPIE - The International Society for Optical Engineering. editor / M.J. Soileau. Vol. 533 SPIE, 1985. pp. 8-14
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