Structure and mechanism of ATP-dependent proteases

Marion Schmidt, Andrei N. Lupas, Daniel Finley

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

A general paradigm for energy-dependent proteases is emerging: ATP may be used to unfold the substrate and translocate it through a narrow channel within the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model.

Original languageEnglish (US)
Pages (from-to)584-591
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume3
Issue number5
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

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ATP-Dependent Proteases
Peptide Hydrolases
Adenosine Triphosphate
Substrates
Enzymes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Structure and mechanism of ATP-dependent proteases. / Schmidt, Marion; Lupas, Andrei N.; Finley, Daniel.

In: Current Opinion in Chemical Biology, Vol. 3, No. 5, 01.10.1999, p. 584-591.

Research output: Contribution to journalArticle

Schmidt, Marion ; Lupas, Andrei N. ; Finley, Daniel. / Structure and mechanism of ATP-dependent proteases. In: Current Opinion in Chemical Biology. 1999 ; Vol. 3, No. 5. pp. 584-591.
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