Structure and functions of the GNAT superfamily of acetyltransferases

Matthew W. Vetting, Luiz Pedro Luiz, Michael Yu, Subray Hegde, Sophie Magnet, Steven L. Roderick, John S. Blanchard

Research output: Contribution to journalArticle

365 Citations (Scopus)

Abstract

The Gcn5-related N-acetyltransferases are an enormous superfamily of enzymes that are universally distributed in nature and that use acyl-CoAs to acylate their cognate substrates. In this review, we will examine those members of this superfamily that have been both structurally and mechanistically characterized. These include aminoglycoside N-acetyltransferases, serotonin N-acetyltransferase, glucosamine-6-phosphate N-acetyltransferase, the histone acetyltransferases, mycothiol synthase, protein N-myristoyltransferase, and the Fem family of amino acyl transferases.

Original languageEnglish (US)
Pages (from-to)212-226
Number of pages15
JournalArchives of Biochemistry and Biophysics
Volume433
Issue number1
DOIs
StatePublished - Jan 1 2005

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Glucosamine 6-Phosphate N-Acetyltransferase
Arylalkylamine N-Acetyltransferase
Histone Acetyltransferases
Acetyltransferases
Aminoglycosides
Transferases
Substrates
Enzymes
Proteins
acetyl-CoA 1-D-myo-inosityl 2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside acetyltransferase
glycylpeptide N-tetradecanoyltransferase
aminoglycoside acetyltransferase

Keywords

  • Acetyltransferase
  • Antibiotic resistance
  • Chemical mechanism
  • GNAT
  • Histone acetyltransferase
  • Protein modification
  • Steady-state kinetics
  • Structure and function of enzymes
  • Three-dimensional structure

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Structure and functions of the GNAT superfamily of acetyltransferases. / Vetting, Matthew W.; Luiz, Luiz Pedro; Yu, Michael; Hegde, Subray; Magnet, Sophie; Roderick, Steven L.; Blanchard, John S.

In: Archives of Biochemistry and Biophysics, Vol. 433, No. 1, 01.01.2005, p. 212-226.

Research output: Contribution to journalArticle

Vetting, Matthew W. ; Luiz, Luiz Pedro ; Yu, Michael ; Hegde, Subray ; Magnet, Sophie ; Roderick, Steven L. ; Blanchard, John S. / Structure and functions of the GNAT superfamily of acetyltransferases. In: Archives of Biochemistry and Biophysics. 2005 ; Vol. 433, No. 1. pp. 212-226.
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