Structure and Function of the Left Atrium and Left Atrial Appendage: AF and Stroke Implications

Victoria Delgado, Luigi Di Biase, Melissa Leung, Jorge E. Romero, Laurens F. Tops, Barbara Casadei, Nassir Marrouche, Jeroen J. Bax

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Atrial fibrillation (AF) and stroke are important major health problems that share common risk factors and frequently coexist. Left atrial (LA) remodeling is an important underlying substrate for AF and stroke. LA dilation and dysfunction form a prothrombotic milieu characterized by blood stasis and endothelial dysfunction. In addition, alterations of the atrial cardiomyocytes, increase of noncollagen deposits in the interstitial space and fibrosis, favor the occurrence of re-entry that predisposes to AF. Eventually, AF further impairs LA function and promotes LA remodeling, closing a self-perpetuating vicious circle. Multimodality imaging provides a comprehensive evaluation of several aspects of LA remodeling and offers several parameters to identify patients at risk of AF and stroke. How multimodality imaging can be integrated in clinical management of patients at risk of AF and stroke is the focus of the present review paper.

Original languageEnglish (US)
Pages (from-to)3157-3172
Number of pages16
JournalJournal of the American College of Cardiology
Volume70
Issue number25
DOIs
StatePublished - Dec 26 2017

Fingerprint

Atrial Appendage
Heart Atria
Atrial Fibrillation
Stroke
Atrial Remodeling
Left Atrial Function
Cardiac Myocytes
Dilatation
Fibrosis
Health

Keywords

  • atrial fibrillation
  • left atrial appendage
  • left atrium
  • multimodality imaging
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Structure and Function of the Left Atrium and Left Atrial Appendage : AF and Stroke Implications. / Delgado, Victoria; Di Biase, Luigi; Leung, Melissa; Romero, Jorge E.; Tops, Laurens F.; Casadei, Barbara; Marrouche, Nassir; Bax, Jeroen J.

In: Journal of the American College of Cardiology, Vol. 70, No. 25, 26.12.2017, p. 3157-3172.

Research output: Contribution to journalReview article

Delgado, Victoria ; Di Biase, Luigi ; Leung, Melissa ; Romero, Jorge E. ; Tops, Laurens F. ; Casadei, Barbara ; Marrouche, Nassir ; Bax, Jeroen J. / Structure and Function of the Left Atrium and Left Atrial Appendage : AF and Stroke Implications. In: Journal of the American College of Cardiology. 2017 ; Vol. 70, No. 25. pp. 3157-3172.
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