Structural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications

Chemical Compounds

• Site-Directed Mutagenesis 76%
• N-Formylkynurenine 60%
• Kynurenine 53%
• Simulation 46%
• Oxidative Elimination Reaction 44%
• Hydrogen 37%
• Tryptophan 34%
• Protein 30%
• Enzyme Activity 30%
• Molecular Dynamics 27%
• Catalysis 23%
• Modification 20%
• Crystal Structure 18%
• Solvent 17%
• Acid 12%

Medicine & Life Sciences

• Indoleamine-Pyrrole 2,3,-Dioxygenase 100%
• Catalytic Domain 66%
• Kynurenine 49%
• Hydrogen Bonding 44%
• Site-Directed Mutagenesis 39%
• Proteins 27%
• Catalysis 22%
• Molecular Dynamics Simulation 20%
• Tryptophan 19%
• Post Translational Protein Processing 19%
• Amino Acids 12%
• Enzymes 10%
• Neoplasms 5%
• Therapeutics 3%