Structural requirements for glycolipid antigen recognition by CD1b- restricted T cells

D. Branch Moody, Bruce B. Reinhold, Mark R. Guy, Evan M. Beckman, Daphney E. Frederique, Stephen T. Furlong, Song Ye, Vernon N. Reinhold, Peter A. Sieling, Robert L. Modlin, Gurdyal S. Besra, Steven A. Porcelli

Research output: Contribution to journalArticle

362 Scopus citations

Abstract

The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM) as a CD1b-presented glycolipid allowed determination of the structural requirements for its recognition by T cells. Presentation of GMM to CD1b-restricted T cells was not affected by substantial variations in its lipid tails, but was extremely sensitive to chemical alterations in its carbohydrate or other polar substituents. These findings support the view that the recently demonstrated hydrophobic CD1 groove binds the acyl chains of lipid antigens relatively nonspecifically, thereby positioning the hydrophilic components for highly specific interactions with T cell antigen receptors.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalScience
Volume278
Issue number5336
DOIs
StatePublished - Oct 10 1997
Externally publishedYes

ASJC Scopus subject areas

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    Moody, D. B., Reinhold, B. B., Guy, M. R., Beckman, E. M., Frederique, D. E., Furlong, S. T., Ye, S., Reinhold, V. N., Sieling, P. A., Modlin, R. L., Besra, G. S., & Porcelli, S. A. (1997). Structural requirements for glycolipid antigen recognition by CD1b- restricted T cells. Science, 278(5336), 283-286. https://doi.org/10.1126/science.278.5336.283