Structural perspectives on BCL-2 family of proteins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

BCL-2 proteins are a family of pro- and anti-apoptotic proteins that regulate a critical step in the mitochondrial apoptotic pathway, the permeabilization of the mitochondrial outer membrane. Because apoptosis and mitochondrial function play an important role in physiology and a number of diseases, intensive investigation over the past two decades has been invested to understand in detail the structure and function of the BCL-2 proteins. Structural biology investigations of BCL-2 proteins have provided tremendous insights into our understanding of their structure-function relationships and models have been proposed to explain how the BCL-2 family members form a network of interactions to control apoptosis signaling. Here, we will review the available structural information of pro- and anti-apoptotic members and the structures of their interaction in homodimerization and heterodimerization. We will discuss the structural insights for each structural domain of BCL-2 proteins that determine their function in the cytosol and the outer mitochondrial membrane. Furthermore, we will discuss the structural details of the interactions between BCL-2 family members and the various structural paradigms that ultimately regulate the activation of apoptosis.

Original languageEnglish (US)
Title of host publicationCell Death: Mechanism and Disease
PublisherSpringer New York
Pages229-251
Number of pages23
ISBN (Print)9781461493020, 1461493013, 9781461493013
DOIs
StatePublished - Nov 1 2013

Fingerprint

Mitochondrial Membranes
Apoptosis
Proteins
Membranes
Apoptosis Regulatory Proteins
Physiology
Cytosol
Chemical activation

Keywords

  • Apoptosis
  • BAX
  • BCL-2
  • BH3 domain
  • BH3-only
  • Cytochrome c
  • Mitochondria
  • MOMP
  • Structure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gavathiotis, E. (2013). Structural perspectives on BCL-2 family of proteins. In Cell Death: Mechanism and Disease (pp. 229-251). Springer New York. https://doi.org/10.1007/978-1-4614-9302-0_11

Structural perspectives on BCL-2 family of proteins. / Gavathiotis, Evripidis.

Cell Death: Mechanism and Disease. Springer New York, 2013. p. 229-251.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gavathiotis, E 2013, Structural perspectives on BCL-2 family of proteins. in Cell Death: Mechanism and Disease. Springer New York, pp. 229-251. https://doi.org/10.1007/978-1-4614-9302-0_11
Gavathiotis E. Structural perspectives on BCL-2 family of proteins. In Cell Death: Mechanism and Disease. Springer New York. 2013. p. 229-251 https://doi.org/10.1007/978-1-4614-9302-0_11
Gavathiotis, Evripidis. / Structural perspectives on BCL-2 family of proteins. Cell Death: Mechanism and Disease. Springer New York, 2013. pp. 229-251
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