Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase

Medicine & Life Sciences

• human indoleamine 2,3-dioxygenase 1 100%
• Indoleamine-Pyrrole 2,3,-Dioxygenase 64%
• epacadostat 48%
• Binding Sites 36%
• Allosteric Site 33%
• indole 31%
• Drug Design 27%
• Glycine 24%
• Drug Development 22%
• Catalytic Domain 21%
• Ethanol 20%
• Mutation 13%
• Enzymes 13%
• Neoplasms 7%

Physics & Astronomy

• inhibitors 55%
• drugs 31%
• effectors 24%
• indoles 23%
• glycine 20%
• mutations 18%
• enzymes 16%
• ethyl alcohol 15%
• escape 15%
• cancer 14%
• activation 12%
• crystal structure 12%
• molecules 8%

Chemical Compounds

• Binding Site 33%
• Effector 25%
• Drug 25%
• Indole 22%
• Glycine 20%
• Mutation 20%
• Ethanol 15%
• Crystal Structure 11%
• Molecule 8%