Structural genomics of protein phosphatases

Steven C. Almo, Jeffrey B. Bonanno, J. Michael Sauder, Spencer Emtage, Teresa P. DiLorenzo, Vladimir Malashkevich, Steven R. Wasserman, S. Swaminathan, Subramaniam Eswaramoorthy, Rakhi Agarwal, Desigan Kumaran, Mahendra Madegowda, Sugadev Ragumani, Yury Patskovsky, Johnjeff Alvarado, Udupi A. Ramagopal, Joana Faber-Barata, Mark R. Chance, Andrej Sali, Andras FiserZhong Yin Zhang, David S. Lawrence, Stephen K. Burley

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

Original languageEnglish (US)
Pages (from-to)121-140
Number of pages20
JournalJournal of Structural and Functional Genomics
Volume8
Issue number2-3
DOIs
StatePublished - Sep 2007

Fingerprint

Phosphoprotein Phosphatases
Genomics
Pathogens
National Institute of General Medical Sciences (U.S.)
African Trypanosomiasis
Anopheles gambiae
Neural Pathways
Trypanosoma brucei brucei
Toxoplasma
Medical problems
Type 1 Diabetes Mellitus
Malaria
Parasites
Throughput
X-Rays
Databases
X rays
Research
Proteins

Keywords

  • NYSGXRC
  • Phosphatase
  • Structural genomics
  • X-ray crystallography

ASJC Scopus subject areas

  • Genetics
  • Structural Biology
  • Biochemistry

Cite this

Structural genomics of protein phosphatases. / Almo, Steven C.; Bonanno, Jeffrey B.; Sauder, J. Michael; Emtage, Spencer; DiLorenzo, Teresa P.; Malashkevich, Vladimir; Wasserman, Steven R.; Swaminathan, S.; Eswaramoorthy, Subramaniam; Agarwal, Rakhi; Kumaran, Desigan; Madegowda, Mahendra; Ragumani, Sugadev; Patskovsky, Yury; Alvarado, Johnjeff; Ramagopal, Udupi A.; Faber-Barata, Joana; Chance, Mark R.; Sali, Andrej; Fiser, Andras; Zhang, Zhong Yin; Lawrence, David S.; Burley, Stephen K.

In: Journal of Structural and Functional Genomics, Vol. 8, No. 2-3, 09.2007, p. 121-140.

Research output: Contribution to journalArticle

Almo, SC, Bonanno, JB, Sauder, JM, Emtage, S, DiLorenzo, TP, Malashkevich, V, Wasserman, SR, Swaminathan, S, Eswaramoorthy, S, Agarwal, R, Kumaran, D, Madegowda, M, Ragumani, S, Patskovsky, Y, Alvarado, J, Ramagopal, UA, Faber-Barata, J, Chance, MR, Sali, A, Fiser, A, Zhang, ZY, Lawrence, DS & Burley, SK 2007, 'Structural genomics of protein phosphatases', Journal of Structural and Functional Genomics, vol. 8, no. 2-3, pp. 121-140. https://doi.org/10.1007/s10969-007-9036-1
Almo, Steven C. ; Bonanno, Jeffrey B. ; Sauder, J. Michael ; Emtage, Spencer ; DiLorenzo, Teresa P. ; Malashkevich, Vladimir ; Wasserman, Steven R. ; Swaminathan, S. ; Eswaramoorthy, Subramaniam ; Agarwal, Rakhi ; Kumaran, Desigan ; Madegowda, Mahendra ; Ragumani, Sugadev ; Patskovsky, Yury ; Alvarado, Johnjeff ; Ramagopal, Udupi A. ; Faber-Barata, Joana ; Chance, Mark R. ; Sali, Andrej ; Fiser, Andras ; Zhang, Zhong Yin ; Lawrence, David S. ; Burley, Stephen K. / Structural genomics of protein phosphatases. In: Journal of Structural and Functional Genomics. 2007 ; Vol. 8, No. 2-3. pp. 121-140.
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