Abstract
Recent advances in nanotechnology offer great opportunities for the application of technogenic nanoparticles (NPs) in biology and medicine. The size of NPs enables their penetration into almost all organs, tissues, cells and cell organelles. The interaction of NPs with proteins can in certain cases lead to structural modification of the protein molecules, resulting in the exposure of previously hidden peptide epitopes on the protein surface and the acquisition of new, nonphysiological functions by the proteins. The adsorption of proteins and peptides on the surface of the NPs can result in an increase in the local concentration of protein molecules, and this can lead to structural and functional changes in the molecules due to increased avidity. The interaction of NPs with proteins and peptides can also induce cooperative effects, thereby changing the rate of formation of fibrillar aggregates of proteins or stimulating the formation of amorphous aggregates of NPs and biomolecules. A thorough understanding of the molecular mechanisms of nano-bio interactions is obviously necessary for the further development of a wide range of applications of nanotechnology. The present review addresses recent advances in the study of the molecular mechanisms of interaction of proteins and peptides with NPs, as well as the possible structural, functional, and toxic effects of these interactions. The data presented in the review may be useful for an analysis of the possible effects of the biomolecular interaction with technogenic NPs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 700-720 |
| Number of pages | 21 |
| Journal | Nanotechnologies in Russia |
| Volume | 8 |
| Issue number | 11-12 |
| DOIs | |
| State | Published - Dec 23 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Engineering(all)
Cite this
Structural and functional aspects of the interaction of proteins and peptides with nanoparticles. / Rumyantsev, K. A.; Shemetov, Anton; Nabiev, I. R.; Sukhanova, A. V.
In: Nanotechnologies in Russia, Vol. 8, No. 11-12, 23.12.2013, p. 700-720.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structural and functional aspects of the interaction of proteins and peptides with nanoparticles
AU - Rumyantsev, K. A.
AU - Shemetov, Anton
AU - Nabiev, I. R.
AU - Sukhanova, A. V.
PY - 2013/12/23
Y1 - 2013/12/23
N2 - Recent advances in nanotechnology offer great opportunities for the application of technogenic nanoparticles (NPs) in biology and medicine. The size of NPs enables their penetration into almost all organs, tissues, cells and cell organelles. The interaction of NPs with proteins can in certain cases lead to structural modification of the protein molecules, resulting in the exposure of previously hidden peptide epitopes on the protein surface and the acquisition of new, nonphysiological functions by the proteins. The adsorption of proteins and peptides on the surface of the NPs can result in an increase in the local concentration of protein molecules, and this can lead to structural and functional changes in the molecules due to increased avidity. The interaction of NPs with proteins and peptides can also induce cooperative effects, thereby changing the rate of formation of fibrillar aggregates of proteins or stimulating the formation of amorphous aggregates of NPs and biomolecules. A thorough understanding of the molecular mechanisms of nano-bio interactions is obviously necessary for the further development of a wide range of applications of nanotechnology. The present review addresses recent advances in the study of the molecular mechanisms of interaction of proteins and peptides with NPs, as well as the possible structural, functional, and toxic effects of these interactions. The data presented in the review may be useful for an analysis of the possible effects of the biomolecular interaction with technogenic NPs.
AB - Recent advances in nanotechnology offer great opportunities for the application of technogenic nanoparticles (NPs) in biology and medicine. The size of NPs enables their penetration into almost all organs, tissues, cells and cell organelles. The interaction of NPs with proteins can in certain cases lead to structural modification of the protein molecules, resulting in the exposure of previously hidden peptide epitopes on the protein surface and the acquisition of new, nonphysiological functions by the proteins. The adsorption of proteins and peptides on the surface of the NPs can result in an increase in the local concentration of protein molecules, and this can lead to structural and functional changes in the molecules due to increased avidity. The interaction of NPs with proteins and peptides can also induce cooperative effects, thereby changing the rate of formation of fibrillar aggregates of proteins or stimulating the formation of amorphous aggregates of NPs and biomolecules. A thorough understanding of the molecular mechanisms of nano-bio interactions is obviously necessary for the further development of a wide range of applications of nanotechnology. The present review addresses recent advances in the study of the molecular mechanisms of interaction of proteins and peptides with NPs, as well as the possible structural, functional, and toxic effects of these interactions. The data presented in the review may be useful for an analysis of the possible effects of the biomolecular interaction with technogenic NPs.
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U2 - 10.1134/S1995078013060116
DO - 10.1134/S1995078013060116
M3 - Article
AN - SCOPUS:84890527574
VL - 8
SP - 700
EP - 720
JO - Nanotechnologies in Russia
JF - Nanotechnologies in Russia
SN - 1995-0780
IS - 11-12
ER -