STROGAR - STrengthening the Reporting of Genetic Association studies in Radiogenomics

Sarah L. Kerns, Dirk De Ruysscher, Christian N. Andreassen, David Azria, Gillian C. Barnett, Jenny Chang-Claude, Susan Davidson, Joseph O. Deasy, Alison M. Dunning, Harry Ostrer, Barry S. Rosenstein, Catharine M.L. West, Søren M. Bentzen

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Despite publication of numerous radiogenomics studies to date, positive single nucleotide polymorphism (SNP) associations have rarely been reproduced in independent validation studies. A major reason for these inconsistencies is a high number of false positive findings because no adjustments were made for multiple comparisons. It is also possible that some validation studies were false negatives due to methodological shortcomings or a failure to reproduce relevant details of the original study. Transparent reporting is needed to ensure these flaws do not hamper progress in radiogenomics. In response to the need for improving the quality of research in the area, the Radiogenomics Consortium produced an 18-item checklist for reporting radiogenomics studies. It is recognised that not all studies will have recorded all of the information included in the checklist. However, authors should report on all checklist items and acknowledge any missing information. Use of STROGAR guidelines will advance the field of radiogenomics by increasing the transparency and completeness of reporting.

Original languageEnglish (US)
Pages (from-to)182-188
Number of pages7
JournalRadiotherapy and Oncology
Volume110
Issue number1
DOIs
StatePublished - Jan 2014

    Fingerprint

Keywords

  • Genetics
  • Normal tissue toxicity
  • Radiogenomics
  • Reporting guidelines

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Kerns, S. L., Ruysscher, D. D., Andreassen, C. N., Azria, D., Barnett, G. C., Chang-Claude, J., Davidson, S., Deasy, J. O., Dunning, A. M., Ostrer, H., Rosenstein, B. S., West, C. M. L., & Bentzen, S. M. (2014). STROGAR - STrengthening the Reporting of Genetic Association studies in Radiogenomics. Radiotherapy and Oncology, 110(1), 182-188. https://doi.org/10.1016/j.radonc.2013.07.011