TY - JOUR
T1 - Striosornal organization of substance P'like immunoreactivity in parkinsonian patients
AU - Sakamoto, Shizuki
AU - Goto, Satoshi
AU - Ito, Hidefumi
AU - Hirano, Asao
PY - 1992/5
Y1 - 1992/5
N2 - We designed this study to evaluate the expression of substance P (SP) in the striatum and the globus pallidus in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). We determinod immunohistochemically the expression of SP in formalin-fxed, paraffin-embedded brain tissues using the free-floating method. In normal controls, we observed SP-like immunoreactivity in the internal segment of the globus pallidus, where the SP-positive fibers showed typical woolly fiber patterns. SP expression in the striatum had the characteristic patchwork of striosomes. Patients with PD showed the normal distribution pattern of SP. By comparison, in paticnts with SND, there was a striking diminution of SP in the putamen, while the SP-positive patches persisted in the caudate nucleus. This study represents the first unequivocal immunohistochemical demonstration of SP-positive striosomes in the human striatum.
AB - We designed this study to evaluate the expression of substance P (SP) in the striatum and the globus pallidus in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). We determinod immunohistochemically the expression of SP in formalin-fxed, paraffin-embedded brain tissues using the free-floating method. In normal controls, we observed SP-like immunoreactivity in the internal segment of the globus pallidus, where the SP-positive fibers showed typical woolly fiber patterns. SP expression in the striatum had the characteristic patchwork of striosomes. Patients with PD showed the normal distribution pattern of SP. By comparison, in paticnts with SND, there was a striking diminution of SP in the putamen, while the SP-positive patches persisted in the caudate nucleus. This study represents the first unequivocal immunohistochemical demonstration of SP-positive striosomes in the human striatum.
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U2 - 10.1212/wnl.42.5.1071
DO - 10.1212/wnl.42.5.1071
M3 - Article
C2 - 1374545
AN - SCOPUS:0026755372
SN - 0028-3878
VL - 42
SP - 1071
EP - 1075
JO - Neurology
JF - Neurology
IS - 5
ER -