Striosomal arrangement of met-enkephalin and substance P expression in parkinsonism-dementia complex on Guam

H. Ito, S. Goto, S. Sakamoto, A. Hirano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This report concerns a topographic immunohistochemcal analysis of Met-enkephalin (MEnk) and substance P (SP) expression in the striatum from seven patients with parkinsonism-dementia complex on Guam (PDC). The striatum of seven neurologically normal subjects served as controls. MEnk-positive striosomes were readily visualized in both the caudate nucleus and the putament of the PDC cases. Although the immunoreactivity was less than that of MEnk, SP-positive patches were detected in the PDC striatum. The patches were similar to those seen in the normal controls. These results provide additional evidence that the striatum and its efferent system appear to be preserved in patients with PDC.

Original languageEnglish (US)
Pages (from-to)390-393
Number of pages4
JournalActa Neuropathologica
Volume85
Issue number4
DOIs
StatePublished - Jul 1993

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Guam
Methionine Enkephalin
Parkinsonian Disorders
Substance P
Dementia
Caudate Nucleus

Keywords

  • Met-enkephalin
  • Parkinsonism-dementia complex on Guam
  • Striatum
  • Striosomes
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Striosomal arrangement of met-enkephalin and substance P expression in parkinsonism-dementia complex on Guam. / Ito, H.; Goto, S.; Sakamoto, S.; Hirano, A.

In: Acta Neuropathologica, Vol. 85, No. 4, 07.1993, p. 390-393.

Research output: Contribution to journalArticle

Ito, H. ; Goto, S. ; Sakamoto, S. ; Hirano, A. / Striosomal arrangement of met-enkephalin and substance P expression in parkinsonism-dementia complex on Guam. In: Acta Neuropathologica. 1993 ; Vol. 85, No. 4. pp. 390-393.
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