Striatal "function-metabolism" mismatch on F-18 FDG/F-18 FDOPA PET/CT

Madhavi Tripathi; Rajnish Sharma; Abhinav Jaimini; Gunjan Garg; Aditi Khurana; Maria D'Souza; Raunak Varshney; Anil Mishra; Anupam Mondal

doi:10.1097/RLU.0b013e3181b53a33

Striatal "function-metabolism" mismatch on F-18 FDG/F-18 FDOPA PET/CT

Madhavi Tripathi, Rajnish Sharma, Abhinav Jaimini, Gunjan Garg, Aditi Khurana, Maria D'Souza, Raunak Varshney, Anil Mishra, Anupam Mondal

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Decrease in gray matter metabolism following cranial irradiation has been documented, but the functional relevance of this finding has not been documented. This case of "function-metabolism" mismatch in the striatum following radiation for a grade III frontoparietal glioma demonstrates that the down-regulation of glucose metabolism as demonstrated by F-18 fluorodeoxyglucose positron emission tomography/computed tomography is associated with preservation of presynaptic dopaminergic function by the striatal neurons which was demonstrated on a correlative l-3,4-dihydroxy-6-F- flurophenylalanine (F-18 FDOPA) study. The reversibility of this down-regulation is demonstrated in a follow-up scan further proving that there is no neurodegeneration involved.

Original language	English (US)
Pages (from-to)	703-705
Number of pages	3
Journal	Clinical nuclear medicine
Volume	34
Issue number	10
DOIs	https://doi.org/10.1097/RLU.0b013e3181b53a33
State	Published - Oct 2009
Externally published	Yes

Keywords

F-18 FDG
F-18 FDOPA
Mismatch
PET/CT

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/RLU.0b013e3181b53a33

Cite this

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title = "Striatal {"}function-metabolism{"} mismatch on F-18 FDG/F-18 FDOPA PET/CT",

abstract = "Decrease in gray matter metabolism following cranial irradiation has been documented, but the functional relevance of this finding has not been documented. This case of {"}function-metabolism{"} mismatch in the striatum following radiation for a grade III frontoparietal glioma demonstrates that the down-regulation of glucose metabolism as demonstrated by F-18 fluorodeoxyglucose positron emission tomography/computed tomography is associated with preservation of presynaptic dopaminergic function by the striatal neurons which was demonstrated on a correlative l-3,4-dihydroxy-6-F- flurophenylalanine (F-18 FDOPA) study. The reversibility of this down-regulation is demonstrated in a follow-up scan further proving that there is no neurodegeneration involved.",

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AU - Tripathi, Madhavi

AU - Sharma, Rajnish

AU - Jaimini, Abhinav

AU - Garg, Gunjan

AU - Khurana, Aditi

AU - D'Souza, Maria

AU - Varshney, Raunak

AU - Mishra, Anil

AU - Mondal, Anupam

PY - 2009/10

Y1 - 2009/10

N2 - Decrease in gray matter metabolism following cranial irradiation has been documented, but the functional relevance of this finding has not been documented. This case of "function-metabolism" mismatch in the striatum following radiation for a grade III frontoparietal glioma demonstrates that the down-regulation of glucose metabolism as demonstrated by F-18 fluorodeoxyglucose positron emission tomography/computed tomography is associated with preservation of presynaptic dopaminergic function by the striatal neurons which was demonstrated on a correlative l-3,4-dihydroxy-6-F- flurophenylalanine (F-18 FDOPA) study. The reversibility of this down-regulation is demonstrated in a follow-up scan further proving that there is no neurodegeneration involved.

AB - Decrease in gray matter metabolism following cranial irradiation has been documented, but the functional relevance of this finding has not been documented. This case of "function-metabolism" mismatch in the striatum following radiation for a grade III frontoparietal glioma demonstrates that the down-regulation of glucose metabolism as demonstrated by F-18 fluorodeoxyglucose positron emission tomography/computed tomography is associated with preservation of presynaptic dopaminergic function by the striatal neurons which was demonstrated on a correlative l-3,4-dihydroxy-6-F- flurophenylalanine (F-18 FDOPA) study. The reversibility of this down-regulation is demonstrated in a follow-up scan further proving that there is no neurodegeneration involved.

KW - F-18 FDG

KW - F-18 FDOPA

KW - Mismatch

KW - PET/CT

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Striatal "function-metabolism" mismatch on F-18 FDG/F-18 FDOPA PET/CT

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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