Abstract
Since the time it was pioneered in 1992, intravital imaging of tumors at cellular resolution has offered us the extremely important opportunity of "seeing biology". However, until now, most studies were monitoring tumor cell behavior in the same animal over short times, requiring the combining of acquired data into a hypothesis via statistical analysis. In the last year, different groups have independently developed techniques to extend the time scale of intravital imaging to several days. This improvement allows one to address the connection between tumor cell behavior and the microenvironment which surrounds them. We can now assess dynamics of the cell-cell interactions in tumors, analyze tumor cell fate and changes in the tumor extracellular matrix which accompany tumor progression.
| Original language | English (US) |
|---|---|
| Journal | Cell Adhesion and Migration |
| Volume | 3 |
| Issue number | 4 |
| State | Published - 2009 |
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Keywords
- Dorsal skinfold chamber
- Intravital
- Mammary imaging window
- Microenvironment
- Multiphoton
- Photoswitching
- Second harmonic generation
- Spinning disc
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology
Cite this
Stretching the timescale of intravital imaging in tumors. / Gligorijevic, Bojana; Condeelis, John S.
In: Cell Adhesion and Migration, Vol. 3, No. 4, 2009.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Stretching the timescale of intravital imaging in tumors
AU - Gligorijevic, Bojana
AU - Condeelis, John S.
PY - 2009
Y1 - 2009
N2 - Since the time it was pioneered in 1992, intravital imaging of tumors at cellular resolution has offered us the extremely important opportunity of "seeing biology". However, until now, most studies were monitoring tumor cell behavior in the same animal over short times, requiring the combining of acquired data into a hypothesis via statistical analysis. In the last year, different groups have independently developed techniques to extend the time scale of intravital imaging to several days. This improvement allows one to address the connection between tumor cell behavior and the microenvironment which surrounds them. We can now assess dynamics of the cell-cell interactions in tumors, analyze tumor cell fate and changes in the tumor extracellular matrix which accompany tumor progression.
AB - Since the time it was pioneered in 1992, intravital imaging of tumors at cellular resolution has offered us the extremely important opportunity of "seeing biology". However, until now, most studies were monitoring tumor cell behavior in the same animal over short times, requiring the combining of acquired data into a hypothesis via statistical analysis. In the last year, different groups have independently developed techniques to extend the time scale of intravital imaging to several days. This improvement allows one to address the connection between tumor cell behavior and the microenvironment which surrounds them. We can now assess dynamics of the cell-cell interactions in tumors, analyze tumor cell fate and changes in the tumor extracellular matrix which accompany tumor progression.
KW - Dorsal skinfold chamber
KW - Intravital
KW - Mammary imaging window
KW - Microenvironment
KW - Multiphoton
KW - Photoswitching
KW - Second harmonic generation
KW - Spinning disc
UR - http://www.scopus.com/inward/record.url?scp=85011939871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011939871&partnerID=8YFLogxK
M3 - Review article
C2 - 19786830
AN - SCOPUS:85011939871
VL - 3
JO - Cell Adhesion and Migration
JF - Cell Adhesion and Migration
SN - 1933-6918
IS - 4
ER -