Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system: an immunohistochemical investigation

S. Kato, A. Hirano, M. Kato, F. Herz, E. Ohama

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive controls. The protein was detected in 14/22 meningiomas and in 6/13 glioblastomas. Tumor cells expressing srp 72 were also found in 4/17 astrocytomas, 2/9 pituitary tumors, 2/14 primitive neuroectodermal tumors and 1/10 medulloblastomas. Whereas the majority (8/10) of the breast carcinoma metastases had tumor cells that expressed srp 72, only 2/11 lung tumor metastases were positively stained. These results document srp 72 expression by a variety of primary and metastatic tumors of the CNS.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalActa neuropathologica
Volume84
Issue number3
DOIs
StatePublished - Aug 1 1992

Keywords

  • Brain tumors
  • Heat-shock protein 72
  • Stress-response protein 72
  • Tumor metastases

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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