Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system

an immunohistochemical investigation

S. Kato, A. Hirano, M. Kato, F. Herz, E. Ohama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive controls. The protein was detected in 14/22 meningiomas and in 6/13 glioblastomas. Tumor cells expressing srp 72 were also found in 4/17 astrocytomas, 2/9 pituitary tumors, 2/14 primitive neuroectodermal tumors and 1/10 medulloblastomas. Whereas the majority (8/10) of the breast carcinoma metastases had tumor cells that expressed srp 72, only 2/11 lung tumor metastases were positively stained. These results document srp 72 expression by a variety of primary and metastatic tumors of the CNS.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalActa Neuropathologica
Volume84
Issue number3
DOIs
StatePublished - Aug 1992

Fingerprint

HSP72 Heat-Shock Proteins
Central Nervous System Neoplasms
Neoplasm Metastasis
Primitive Neuroectodermal Tumors
Neoplasms
Medulloblastoma
Astrocytoma
Pituitary Neoplasms
Meningioma
Glioblastoma
Brain Neoplasms
Uterine Cervical Neoplasms
Central Nervous System
Breast Neoplasms
Carcinoma
Lung
Proteins

Keywords

  • Brain tumors
  • Heat-shock protein 72
  • Stress-response protein 72
  • Tumor metastases

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system : an immunohistochemical investigation. / Kato, S.; Hirano, A.; Kato, M.; Herz, F.; Ohama, E.

In: Acta Neuropathologica, Vol. 84, No. 3, 08.1992, p. 261-264.

Research output: Contribution to journalArticle

Kato, S. ; Hirano, A. ; Kato, M. ; Herz, F. ; Ohama, E. / Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system : an immunohistochemical investigation. In: Acta Neuropathologica. 1992 ; Vol. 84, No. 3. pp. 261-264.
@article{ceafc5d7bb1a47de8d71a4a0ce5e027b,
title = "Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system: an immunohistochemical investigation",
abstract = "This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive controls. The protein was detected in 14/22 meningiomas and in 6/13 glioblastomas. Tumor cells expressing srp 72 were also found in 4/17 astrocytomas, 2/9 pituitary tumors, 2/14 primitive neuroectodermal tumors and 1/10 medulloblastomas. Whereas the majority (8/10) of the breast carcinoma metastases had tumor cells that expressed srp 72, only 2/11 lung tumor metastases were positively stained. These results document srp 72 expression by a variety of primary and metastatic tumors of the CNS.",
keywords = "Brain tumors, Heat-shock protein 72, Stress-response protein 72, Tumor metastases",
author = "S. Kato and A. Hirano and M. Kato and F. Herz and E. Ohama",
year = "1992",
month = "8",
doi = "10.1007/BF00227818",
language = "English (US)",
volume = "84",
pages = "261--264",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system

T2 - an immunohistochemical investigation

AU - Kato, S.

AU - Hirano, A.

AU - Kato, M.

AU - Herz, F.

AU - Ohama, E.

PY - 1992/8

Y1 - 1992/8

N2 - This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive controls. The protein was detected in 14/22 meningiomas and in 6/13 glioblastomas. Tumor cells expressing srp 72 were also found in 4/17 astrocytomas, 2/9 pituitary tumors, 2/14 primitive neuroectodermal tumors and 1/10 medulloblastomas. Whereas the majority (8/10) of the breast carcinoma metastases had tumor cells that expressed srp 72, only 2/11 lung tumor metastases were positively stained. These results document srp 72 expression by a variety of primary and metastatic tumors of the CNS.

AB - This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive controls. The protein was detected in 14/22 meningiomas and in 6/13 glioblastomas. Tumor cells expressing srp 72 were also found in 4/17 astrocytomas, 2/9 pituitary tumors, 2/14 primitive neuroectodermal tumors and 1/10 medulloblastomas. Whereas the majority (8/10) of the breast carcinoma metastases had tumor cells that expressed srp 72, only 2/11 lung tumor metastases were positively stained. These results document srp 72 expression by a variety of primary and metastatic tumors of the CNS.

KW - Brain tumors

KW - Heat-shock protein 72

KW - Stress-response protein 72

KW - Tumor metastases

UR - http://www.scopus.com/inward/record.url?scp=0026744506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026744506&partnerID=8YFLogxK

U2 - 10.1007/BF00227818

DO - 10.1007/BF00227818

M3 - Article

VL - 84

SP - 261

EP - 264

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 3

ER -