Stress radionuclide myocardial perfusion imaging detects more residual ischemia than stress echocardiography following acute myocardial infarction

Kenneth B. Harris, Michele Nanna, V. S. Srinivas, Alexander Del Vecchio, Garet M. Gordon, Macduff Sheehy, David G. DiMattia, Kimberly D. Weltman, Mark I. Travin

Research output: Contribution to journalArticle

Abstract

Objectives: This investigation sought to compare the abilities of stress radionuclide myocardial perfusion imaging and stress echocardiography to detect residual ischemia in patients following acute myocardial infarction (MI). Background: Stress radionuclide myocardial perfusion imaging and stress echocardiography are both commonly used to assess patients (patients.) in the immediate post MI period. However, the relative value of these techniques in identifying post MI ischemia remains unclear. Methods: Eighteen patients, underwent both dipyridamole radionuclide perfusion imaging and dobutamine stress echocardiography on the same day or on consecutive days, 3-7 days following uncomplicated acute MI. Pts. who had an acute percutaneous intervention were excluded. Images were reviewed with clinical information available, but blinded to the opposing modality, for perfusion defects, wall motion abnormalities (WMA), and evidence of ischemia (reversible defect(s) on perfusion imaging, worsening WMA on stress echocardiography). Of the 18 patients, 11 subsequently underwent cardiac catheterization. Results: Perfusion imaging identified defects in 16 (89%) patients, of whom 15 (83% of total) were found to be ischemic. Stress echocardiography identified a fixed wall motion abnormality in 17 (94%) and ischemia in 8 (44%, p < 0.05 compared with perfusion imaging ischemia). Among 11 patients who underwent catheterization, there was a trend towards perfusion imaging identifying more ischemia in the territory of an obstructed (≥70%) vessel -100% (11/11) vs. 64% (7/11) for stress echocardiography (p = 0.09). Conclusion: In the immediate postinfarction period, dipyridamole stress radionuclide myocardial perfusion imaging more often shows evidence of residual ischemia than dobutamine stress echocardiography.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalInternational Journal of Cardiovascular Imaging
Volume20
Issue number2
DOIs
StatePublished - Apr 2004

Fingerprint

Stress Echocardiography
Myocardial Perfusion Imaging
Radioisotopes
Perfusion Imaging
Ischemia
Myocardial Infarction
Dipyridamole
Cardiac Catheterization
Catheterization
Radionuclide Imaging
Myocardial Ischemia
Perfusion

Keywords

  • Myocardial infarction
  • Radionuclide myocardial perfusion imaging
  • Stress echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine
  • Radiological and Ultrasound Technology

Cite this

Stress radionuclide myocardial perfusion imaging detects more residual ischemia than stress echocardiography following acute myocardial infarction. / Harris, Kenneth B.; Nanna, Michele; Srinivas, V. S.; Del Vecchio, Alexander; Gordon, Garet M.; Sheehy, Macduff; DiMattia, David G.; Weltman, Kimberly D.; Travin, Mark I.

In: International Journal of Cardiovascular Imaging, Vol. 20, No. 2, 04.2004, p. 145-154.

Research output: Contribution to journalArticle

Harris, Kenneth B. ; Nanna, Michele ; Srinivas, V. S. ; Del Vecchio, Alexander ; Gordon, Garet M. ; Sheehy, Macduff ; DiMattia, David G. ; Weltman, Kimberly D. ; Travin, Mark I. / Stress radionuclide myocardial perfusion imaging detects more residual ischemia than stress echocardiography following acute myocardial infarction. In: International Journal of Cardiovascular Imaging. 2004 ; Vol. 20, No. 2. pp. 145-154.
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abstract = "Objectives: This investigation sought to compare the abilities of stress radionuclide myocardial perfusion imaging and stress echocardiography to detect residual ischemia in patients following acute myocardial infarction (MI). Background: Stress radionuclide myocardial perfusion imaging and stress echocardiography are both commonly used to assess patients (patients.) in the immediate post MI period. However, the relative value of these techniques in identifying post MI ischemia remains unclear. Methods: Eighteen patients, underwent both dipyridamole radionuclide perfusion imaging and dobutamine stress echocardiography on the same day or on consecutive days, 3-7 days following uncomplicated acute MI. Pts. who had an acute percutaneous intervention were excluded. Images were reviewed with clinical information available, but blinded to the opposing modality, for perfusion defects, wall motion abnormalities (WMA), and evidence of ischemia (reversible defect(s) on perfusion imaging, worsening WMA on stress echocardiography). Of the 18 patients, 11 subsequently underwent cardiac catheterization. Results: Perfusion imaging identified defects in 16 (89{\%}) patients, of whom 15 (83{\%} of total) were found to be ischemic. Stress echocardiography identified a fixed wall motion abnormality in 17 (94{\%}) and ischemia in 8 (44{\%}, p < 0.05 compared with perfusion imaging ischemia). Among 11 patients who underwent catheterization, there was a trend towards perfusion imaging identifying more ischemia in the territory of an obstructed (≥70{\%}) vessel -100{\%} (11/11) vs. 64{\%} (7/11) for stress echocardiography (p = 0.09). Conclusion: In the immediate postinfarction period, dipyridamole stress radionuclide myocardial perfusion imaging more often shows evidence of residual ischemia than dobutamine stress echocardiography.",
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T1 - Stress radionuclide myocardial perfusion imaging detects more residual ischemia than stress echocardiography following acute myocardial infarction

AU - Harris, Kenneth B.

AU - Nanna, Michele

AU - Srinivas, V. S.

AU - Del Vecchio, Alexander

AU - Gordon, Garet M.

AU - Sheehy, Macduff

AU - DiMattia, David G.

AU - Weltman, Kimberly D.

AU - Travin, Mark I.

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N2 - Objectives: This investigation sought to compare the abilities of stress radionuclide myocardial perfusion imaging and stress echocardiography to detect residual ischemia in patients following acute myocardial infarction (MI). Background: Stress radionuclide myocardial perfusion imaging and stress echocardiography are both commonly used to assess patients (patients.) in the immediate post MI period. However, the relative value of these techniques in identifying post MI ischemia remains unclear. Methods: Eighteen patients, underwent both dipyridamole radionuclide perfusion imaging and dobutamine stress echocardiography on the same day or on consecutive days, 3-7 days following uncomplicated acute MI. Pts. who had an acute percutaneous intervention were excluded. Images were reviewed with clinical information available, but blinded to the opposing modality, for perfusion defects, wall motion abnormalities (WMA), and evidence of ischemia (reversible defect(s) on perfusion imaging, worsening WMA on stress echocardiography). Of the 18 patients, 11 subsequently underwent cardiac catheterization. Results: Perfusion imaging identified defects in 16 (89%) patients, of whom 15 (83% of total) were found to be ischemic. Stress echocardiography identified a fixed wall motion abnormality in 17 (94%) and ischemia in 8 (44%, p < 0.05 compared with perfusion imaging ischemia). Among 11 patients who underwent catheterization, there was a trend towards perfusion imaging identifying more ischemia in the territory of an obstructed (≥70%) vessel -100% (11/11) vs. 64% (7/11) for stress echocardiography (p = 0.09). Conclusion: In the immediate postinfarction period, dipyridamole stress radionuclide myocardial perfusion imaging more often shows evidence of residual ischemia than dobutamine stress echocardiography.

AB - Objectives: This investigation sought to compare the abilities of stress radionuclide myocardial perfusion imaging and stress echocardiography to detect residual ischemia in patients following acute myocardial infarction (MI). Background: Stress radionuclide myocardial perfusion imaging and stress echocardiography are both commonly used to assess patients (patients.) in the immediate post MI period. However, the relative value of these techniques in identifying post MI ischemia remains unclear. Methods: Eighteen patients, underwent both dipyridamole radionuclide perfusion imaging and dobutamine stress echocardiography on the same day or on consecutive days, 3-7 days following uncomplicated acute MI. Pts. who had an acute percutaneous intervention were excluded. Images were reviewed with clinical information available, but blinded to the opposing modality, for perfusion defects, wall motion abnormalities (WMA), and evidence of ischemia (reversible defect(s) on perfusion imaging, worsening WMA on stress echocardiography). Of the 18 patients, 11 subsequently underwent cardiac catheterization. Results: Perfusion imaging identified defects in 16 (89%) patients, of whom 15 (83% of total) were found to be ischemic. Stress echocardiography identified a fixed wall motion abnormality in 17 (94%) and ischemia in 8 (44%, p < 0.05 compared with perfusion imaging ischemia). Among 11 patients who underwent catheterization, there was a trend towards perfusion imaging identifying more ischemia in the territory of an obstructed (≥70%) vessel -100% (11/11) vs. 64% (7/11) for stress echocardiography (p = 0.09). Conclusion: In the immediate postinfarction period, dipyridamole stress radionuclide myocardial perfusion imaging more often shows evidence of residual ischemia than dobutamine stress echocardiography.

KW - Myocardial infarction

KW - Radionuclide myocardial perfusion imaging

KW - Stress echocardiography

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