Two cases of septicemia with Streptococcus equinus, a group D streptococcus, are reported, and the literature pertaining to infections with this organism is reviewed. Both of our patients presented with obvious signs of infection, had S. equinus isolated from multiple blood cultures, and had a good clinical response to penicillin therapy, alone or in combination with streptomycin. In vitro testing of the isolates confirmed susceptibility to penicillin. S. equinus should now be recognized as a human pathogen as are the other group D streptococci, S. bovis and the enterococci.
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