Streptococcal toxic shock syndrome due to noninvasive pharyngitis

Edward K. Chapnick; Jeremy D. Gradon; Larry I. Lutwick; John Kim; Michael Levi; Michael H. Kim; Patrick M. Schlievert

doi:10.1093/clinids/14.5.1074

Streptococcal toxic shock syndrome due to noninvasive pharyngitis

Edward K. Chapnick, Jeremy D. Gradon, Larry I. Lutwick, John Kim, Michael Levi, Michael H. Kim, Patrick M. Schlievert

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Serious infections due to group A β-hemolytic streptococcus (GABHS) have been reported with increasing frequency in recent years. We report a case of toxic shock syndrome (TSS) due to GABHS pharyngitis in an otherwise healthy 14-year-old boy. The organism was found to produce toxin A. To our knowledge, this is the second reported case of streptococcal TSS associated with the production of toxin A that is not associated with an invasive disease and the first case associated with a documented rise in the level of antibody to the streptococcal toxin itself. Clinicians must be especially vigilant for this entity in patients who have streptococcal pharyngitis because early recognition and institution of aggressive supportive therapy can be lifesaving.

Original language	English (US)
Pages (from-to)	1074-1077
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	14
Issue number	5
DOIs	https://doi.org/10.1093/clinids/14.5.1074
State	Published - May 1 1992
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/clinids/14.5.1074

Cite this

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title = "Streptococcal toxic shock syndrome due to noninvasive pharyngitis",

abstract = "Serious infections due to group A β-hemolytic streptococcus (GABHS) have been reported with increasing frequency in recent years. We report a case of toxic shock syndrome (TSS) due to GABHS pharyngitis in an otherwise healthy 14-year-old boy. The organism was found to produce toxin A. To our knowledge, this is the second reported case of streptococcal TSS associated with the production of toxin A that is not associated with an invasive disease and the first case associated with a documented rise in the level of antibody to the streptococcal toxin itself. Clinicians must be especially vigilant for this entity in patients who have streptococcal pharyngitis because early recognition and institution of aggressive supportive therapy can be lifesaving.",

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AU - Chapnick, Edward K.

AU - Gradon, Jeremy D.

AU - Lutwick, Larry I.

AU - Kim, John

AU - Levi, Michael

AU - Kim, Michael H.

AU - Schlievert, Patrick M.

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AB - Serious infections due to group A β-hemolytic streptococcus (GABHS) have been reported with increasing frequency in recent years. We report a case of toxic shock syndrome (TSS) due to GABHS pharyngitis in an otherwise healthy 14-year-old boy. The organism was found to produce toxin A. To our knowledge, this is the second reported case of streptococcal TSS associated with the production of toxin A that is not associated with an invasive disease and the first case associated with a documented rise in the level of antibody to the streptococcal toxin itself. Clinicians must be especially vigilant for this entity in patients who have streptococcal pharyngitis because early recognition and institution of aggressive supportive therapy can be lifesaving.

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Streptococcal toxic shock syndrome due to noninvasive pharyngitis

Abstract

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