Strength of laser vascular fusion

Preliminary observations on the role of Thrombus

M. C. Oz, L. S. Bass, Roy S. Chuck, J. P. Johnson, S. Parangi, R. Nowygrod, M. R. Treat

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We hypothesized that autologous clot deposited on the luminal surface of laser vascular welds immediately after creation would produce higher time zero bursting pressures than could be achieved in welds perfused with saline alone. To test this hypothesis, we compared bursting pressures of welds created in isolated rabbit aortic segments 1) with saline perfusion only, 2) with blood perfusion, and 3) with blood perfusion followed by infusion of urokinase. Tissue welds with saline perfusion had a mean bursting pressure of 159 ± 45 mm Hg; tissue welds following blood perfusion had a mean pressure of 262 ± 29 mm Hg; tissue welds with blood perfusion followed by urokinase infusion had a mean bursting pressure of 187 ± 35 mm Hg. The saline and urokinase groups were not significantly different. However, the blood-perfused group was significantly higher than both the saline group and the urokinase group. Thus, the addition of urokinase eliminates the beneficial effects noted after blood reperfusion. These observations suggest that the enhancement of weld strength following exposure to blood is due predominantly to the adherence of fibrin-platelet aggregates at the site of the weld.

Original languageEnglish (US)
Pages (from-to)393-395
Number of pages3
JournalLasers in Surgery and Medicine
Volume10
Issue number4
DOIs
StatePublished - 1990
Externally publishedYes

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Urokinase-Type Plasminogen Activator
Blood Vessels
Lasers
Thrombosis
Perfusion
Pressure
Blood Group Antigens
Fibrin
Reperfusion
Blood Platelets
Rabbits

ASJC Scopus subject areas

  • Surgery

Cite this

Oz, M. C., Bass, L. S., Chuck, R. S., Johnson, J. P., Parangi, S., Nowygrod, R., & Treat, M. R. (1990). Strength of laser vascular fusion: Preliminary observations on the role of Thrombus. Lasers in Surgery and Medicine, 10(4), 393-395. https://doi.org/10.1002/lsm.1900100414

Strength of laser vascular fusion : Preliminary observations on the role of Thrombus. / Oz, M. C.; Bass, L. S.; Chuck, Roy S.; Johnson, J. P.; Parangi, S.; Nowygrod, R.; Treat, M. R.

In: Lasers in Surgery and Medicine, Vol. 10, No. 4, 1990, p. 393-395.

Research output: Contribution to journalArticle

Oz, MC, Bass, LS, Chuck, RS, Johnson, JP, Parangi, S, Nowygrod, R & Treat, MR 1990, 'Strength of laser vascular fusion: Preliminary observations on the role of Thrombus', Lasers in Surgery and Medicine, vol. 10, no. 4, pp. 393-395. https://doi.org/10.1002/lsm.1900100414
Oz, M. C. ; Bass, L. S. ; Chuck, Roy S. ; Johnson, J. P. ; Parangi, S. ; Nowygrod, R. ; Treat, M. R. / Strength of laser vascular fusion : Preliminary observations on the role of Thrombus. In: Lasers in Surgery and Medicine. 1990 ; Vol. 10, No. 4. pp. 393-395.
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