Strategies for the prevention of cytomegalovirus infection and disease in pediatric liver transplantation recipients

Cytomegalovirus (CMV) is the most common opportunistic infection following solid organ transplantation. Prevention and management of CMV infection has assumed a higher priority as transplantation has become a frequent treatment for many congenital and acquired disorders, as more potent immunosuppressive agents have become available, new molecular and virologic assays to detect CMV have made their way from research to clinical laboratories and new antiviral medications and biologics have been developed. Management strategies are diverse; however, there are little or no data from large controlled pediatric trials demonstrating the superiority of any particular approach. This review outlines the current strategies employed to prevent CMV infection and disease and summarizes the strengths and limitations of each regimen to guide clinicians in the selection of the optimal preventative approach.