Abstract
Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental B-cell immunobiology and use of newly developed B-cell-directed agents.
Original language | English (US) |
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Pages (from-to) | 1-4 |
Number of pages | 4 |
Journal | Immunologic Research |
Volume | 51 |
Issue number | 1 |
DOIs | |
State | Published - Oct 2011 |
Externally published | Yes |
Keywords
- B-cell
- BLyS
- Humoral tolerance
- Transplantation
ASJC Scopus subject areas
- Immunology