Strategies for B-lymphocyte repertoire remodeling in transplantation tolerance

Kumar Vivek, Moiz M. Mustafa, Eduardo Rodriguez, Robert R. Redfield, Ronald F. Parsons, Susan Rostami, Thi Sau Migone, Michael P. Cancro, Ali Naji, Hooman Noorchashm

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental B-cell immunobiology and use of newly developed B-cell-directed agents.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalImmunologic Research
Volume51
Issue number1
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Keywords

  • B-cell
  • BLyS
  • Humoral tolerance
  • Transplantation

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Vivek, K., Mustafa, M. M., Rodriguez, E., Redfield, R. R., Parsons, R. F., Rostami, S., Migone, T. S., Cancro, M. P., Naji, A., & Noorchashm, H. (2011). Strategies for B-lymphocyte repertoire remodeling in transplantation tolerance. Immunologic Research, 51(1), 1-4. https://doi.org/10.1007/s12026-011-8246-6