Strategic Approaches to Target the Enzymes using Natural Compounds for the Management of Alzheimer’s Disease: A Review

Syed Sayeed Ahmad, Kaiser Younis, Jeandet Philippe, Michael Aschner, Haroon Khan

Research output: Contribution to journalReview articlepeer-review

Abstract

Alzheimer's Disease (AD) is a chronic neurodegenerative disease. It is clinically charac-terized by memory loss and intellectual decrease, among other neurological deficits. The etiology of AD is not completely understood but includes amyloid plaques and intracellular helical fila-ments as well as neurofibrillary tangles with hyperphosphorylated tau protein. AD is also associated with alterations in amyloid processing genes, such as PSEN1 or PSEN2 and APP. The modulation of the immune system, cholesterol metabolism, and synaptic vesicle endocytosis have all been shown to remediate AD. In this review, enzymes such as AChE, BuChE, β-secretase, γ-secretase, MAO, and RAGE are discussed as potential targets for AD treatment. The aim of this review was to address the molecular mechanisms as well as various genetic factors in AD etiology. The use of natural compounds against these targets might be beneficial for the management of AD.

Original languageEnglish (US)
Pages (from-to)610-620
Number of pages11
JournalCNS and Neurological Disorders - Drug Targets
Volume21
Issue number7
DOIs
StatePublished - Aug 2022

Keywords

  • AchE
  • Alzheimer disease
  • BuChE
  • MAO
  • string database
  • γ-Secretase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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