Abstract
Alzheimer's Disease (AD) is a chronic neurodegenerative disease. It is clinically charac-terized by memory loss and intellectual decrease, among other neurological deficits. The etiology of AD is not completely understood but includes amyloid plaques and intracellular helical fila-ments as well as neurofibrillary tangles with hyperphosphorylated tau protein. AD is also associated with alterations in amyloid processing genes, such as PSEN1 or PSEN2 and APP. The modulation of the immune system, cholesterol metabolism, and synaptic vesicle endocytosis have all been shown to remediate AD. In this review, enzymes such as AChE, BuChE, β-secretase, γ-secretase, MAO, and RAGE are discussed as potential targets for AD treatment. The aim of this review was to address the molecular mechanisms as well as various genetic factors in AD etiology. The use of natural compounds against these targets might be beneficial for the management of AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 610-620 |
| Number of pages | 11 |
| Journal | CNS and Neurological Disorders - Drug Targets |
| Volume | 21 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 2022 |
Keywords
- AchE
- Alzheimer disease
- BuChE
- MAO
- string database
- γ-Secretase
ASJC Scopus subject areas
- Neuroscience(all)
- Pharmacology