Strategic Approaches to Target the Enzymes using Natural Compounds for the Management of Alzheimer’s Disease: A Review

Syed Sayeed Ahmad; Kaiser Younis; Jeandet Philippe; Michael Aschner; Haroon Khan

doi:10.2174/1871527320666210811160007

Strategic Approaches to Target the Enzymes using Natural Compounds for the Management of Alzheimer’s Disease: A Review

Syed Sayeed Ahmad, Kaiser Younis, Jeandet Philippe, Michael Aschner, Haroon Khan

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Alzheimer's Disease (AD) is a chronic neurodegenerative disease. It is clinically charac-terized by memory loss and intellectual decrease, among other neurological deficits. The etiology of AD is not completely understood but includes amyloid plaques and intracellular helical fila-ments as well as neurofibrillary tangles with hyperphosphorylated tau protein. AD is also associated with alterations in amyloid processing genes, such as PSEN1 or PSEN2 and APP. The modulation of the immune system, cholesterol metabolism, and synaptic vesicle endocytosis have all been shown to remediate AD. In this review, enzymes such as AChE, BuChE, β-secretase, γ-secretase, MAO, and RAGE are discussed as potential targets for AD treatment. The aim of this review was to address the molecular mechanisms as well as various genetic factors in AD etiology. The use of natural compounds against these targets might be beneficial for the management of AD.

Original language	English (US)
Pages (from-to)	610-620
Number of pages	11
Journal	CNS and Neurological Disorders - Drug Targets
Volume	21
Issue number	7
DOIs	https://doi.org/10.2174/1871527320666210811160007
State	Published - Aug 2022

Keywords

AchE
Alzheimer disease
BuChE
MAO
string database
γ-Secretase

ASJC Scopus subject areas

General Neuroscience
Pharmacology

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10.2174/1871527320666210811160007

Cite this

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title = "Strategic Approaches to Target the Enzymes using Natural Compounds for the Management of Alzheimer{\textquoteright}s Disease: A Review",

abstract = "Alzheimer's Disease (AD) is a chronic neurodegenerative disease. It is clinically charac-terized by memory loss and intellectual decrease, among other neurological deficits. The etiology of AD is not completely understood but includes amyloid plaques and intracellular helical fila-ments as well as neurofibrillary tangles with hyperphosphorylated tau protein. AD is also associated with alterations in amyloid processing genes, such as PSEN1 or PSEN2 and APP. The modulation of the immune system, cholesterol metabolism, and synaptic vesicle endocytosis have all been shown to remediate AD. In this review, enzymes such as AChE, BuChE, β-secretase, γ-secretase, MAO, and RAGE are discussed as potential targets for AD treatment. The aim of this review was to address the molecular mechanisms as well as various genetic factors in AD etiology. The use of natural compounds against these targets might be beneficial for the management of AD.",

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doi = "10.2174/1871527320666210811160007",

language = "English (US)",

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AU - Philippe, Jeandet

AU - Aschner, Michael

AU - Khan, Haroon

PY - 2022/8

Y1 - 2022/8

N2 - Alzheimer's Disease (AD) is a chronic neurodegenerative disease. It is clinically charac-terized by memory loss and intellectual decrease, among other neurological deficits. The etiology of AD is not completely understood but includes amyloid plaques and intracellular helical fila-ments as well as neurofibrillary tangles with hyperphosphorylated tau protein. AD is also associated with alterations in amyloid processing genes, such as PSEN1 or PSEN2 and APP. The modulation of the immune system, cholesterol metabolism, and synaptic vesicle endocytosis have all been shown to remediate AD. In this review, enzymes such as AChE, BuChE, β-secretase, γ-secretase, MAO, and RAGE are discussed as potential targets for AD treatment. The aim of this review was to address the molecular mechanisms as well as various genetic factors in AD etiology. The use of natural compounds against these targets might be beneficial for the management of AD.

AB - Alzheimer's Disease (AD) is a chronic neurodegenerative disease. It is clinically charac-terized by memory loss and intellectual decrease, among other neurological deficits. The etiology of AD is not completely understood but includes amyloid plaques and intracellular helical fila-ments as well as neurofibrillary tangles with hyperphosphorylated tau protein. AD is also associated with alterations in amyloid processing genes, such as PSEN1 or PSEN2 and APP. The modulation of the immune system, cholesterol metabolism, and synaptic vesicle endocytosis have all been shown to remediate AD. In this review, enzymes such as AChE, BuChE, β-secretase, γ-secretase, MAO, and RAGE are discussed as potential targets for AD treatment. The aim of this review was to address the molecular mechanisms as well as various genetic factors in AD etiology. The use of natural compounds against these targets might be beneficial for the management of AD.

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KW - BuChE

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Strategic Approaches to Target the Enzymes using Natural Compounds for the Management of Alzheimer’s Disease: A Review

Abstract

Keywords

ASJC Scopus subject areas

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