Stimulus-Driven Population Activity Patterns in Macaque Primary Visual Cortex

Benjamin R. Cowley, Matthew A. Smith, Adam Kohn, Byron M. Yu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Dimensionality reduction has been applied in various brain areas to study the activity of populations of neurons. To interpret the outputs of dimensionality reduction, it is important to first understand its outputs for brain areas for which the relationship between the stimulus and neural response is well characterized. Here, we applied principal component analysis (PCA) to trial-averaged neural responses in macaque primary visual cortex (V1) to study two fundamental, population-level questions. First, we characterized how neural complexity relates to stimulus complexity, where complexity is measured using relative comparisons of dimensionality. Second, we assessed the extent to which responses to different stimuli occupy similar dimensions of the population activity space using a novel statistical method. For comparison, we performed the same dimensionality reduction analyses on the activity of a recently-proposed V1 receptive field model and a deep convolutional neural network. Our results show that the dimensionality of the population response changes systematically with alterations in the properties and complexity of the visual stimulus.

Original languageEnglish (US)
Article numbere1005185
JournalPLoS Computational Biology
Volume12
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Visual Cortex
Macaca
activity pattern
Dimensionality Reduction
Brain
Population
Dimensionality
brain
Receptive Field
Principal component analysis
Neurons
visual cue
Output
Statistical methods
Principal Component Analysis
Statistical method
neural networks
Neural networks
Neuron
principal component analysis

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

Cite this

Stimulus-Driven Population Activity Patterns in Macaque Primary Visual Cortex. / Cowley, Benjamin R.; Smith, Matthew A.; Kohn, Adam; Yu, Byron M.

In: PLoS Computational Biology, Vol. 12, No. 12, e1005185, 01.12.2016.

Research output: Contribution to journalArticle

Cowley, Benjamin R. ; Smith, Matthew A. ; Kohn, Adam ; Yu, Byron M. / Stimulus-Driven Population Activity Patterns in Macaque Primary Visual Cortex. In: PLoS Computational Biology. 2016 ; Vol. 12, No. 12.
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