Stimulation and Inhibition by Normal Human Serum of Colony Formation in Vitro by Bone Marrow Cells

S. H. Chan; D. Metcalf; E. R. Stanley

doi:10.1111/j.1365-2141.1971.tb07043.x

Stimulation and Inhibition by Normal Human Serum of Colony Formation in Vitro by Bone Marrow Cells

S. H. Chan, D. Metcalf, E. R. Stanley

Developmental & Molecular Biology

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Summary. Normal human sera were able to stimulate granulocyte and macrophage colony formation in vitro by mouse bone marrow cells, but only following removal of inhibitory material either by dialysis or by heat‐ or ether‐treatment. Inhibitors were shown to be present in all normal human sera tested, to exhibit partial species specificity, to be multiple and to be probably lipoprotein in nature. The in vivo function of these inhibitors is unknown but they may modulate the action of the colony stimulating factor (CSF) in stimulating granulopoiesis and macrophage formation.

Original language	English (US)
Pages (from-to)	329-341
Number of pages	13
Journal	British Journal of Haematology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.1971.tb07043.x
State	Published - Mar 1971

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Hematology

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N2 - Summary. Normal human sera were able to stimulate granulocyte and macrophage colony formation in vitro by mouse bone marrow cells, but only following removal of inhibitory material either by dialysis or by heat‐ or ether‐treatment. Inhibitors were shown to be present in all normal human sera tested, to exhibit partial species specificity, to be multiple and to be probably lipoprotein in nature. The in vivo function of these inhibitors is unknown but they may modulate the action of the colony stimulating factor (CSF) in stimulating granulopoiesis and macrophage formation.

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Stimulation and Inhibition by Normal Human Serum of Colony Formation in Vitro by Bone Marrow Cells

Abstract

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