Abstract
BACKGROUND Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. After 2 days, she reported vaginal pain. Three days later, she was hospitalized with vulvovaginal ulcerations and restarted on trimethoprim-sulfamethoxazole, leading to worsening vaginal lesions with rapid desquamation of conjunctival and oropharyngeal involvement. Biopsies of arm lesions revealed SJS. CONCLUSIONS It is important to recognize SJS as a rare but life-threatening cause of vulvovaginal ulceration, as early diagnosis is vital for successful treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1519-1521 |
| Number of pages | 3 |
| Journal | The American journal of case reports |
| Volume | 19 |
| DOIs | |
| State | Published - Dec 21 2018 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation. / Mergler, Reid; Chuang, Meleen.
In: The American journal of case reports, Vol. 19, 21.12.2018, p. 1519-1521.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
AU - Mergler, Reid
AU - Chuang, Meleen
PY - 2018/12/21
Y1 - 2018/12/21
N2 - BACKGROUND Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. After 2 days, she reported vaginal pain. Three days later, she was hospitalized with vulvovaginal ulcerations and restarted on trimethoprim-sulfamethoxazole, leading to worsening vaginal lesions with rapid desquamation of conjunctival and oropharyngeal involvement. Biopsies of arm lesions revealed SJS. CONCLUSIONS It is important to recognize SJS as a rare but life-threatening cause of vulvovaginal ulceration, as early diagnosis is vital for successful treatment.
AB - BACKGROUND Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. After 2 days, she reported vaginal pain. Three days later, she was hospitalized with vulvovaginal ulcerations and restarted on trimethoprim-sulfamethoxazole, leading to worsening vaginal lesions with rapid desquamation of conjunctival and oropharyngeal involvement. Biopsies of arm lesions revealed SJS. CONCLUSIONS It is important to recognize SJS as a rare but life-threatening cause of vulvovaginal ulceration, as early diagnosis is vital for successful treatment.
UR - http://www.scopus.com/inward/record.url?scp=85058910020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058910020&partnerID=8YFLogxK
U2 - 10.12659/AJCR.912123
DO - 10.12659/AJCR.912123
M3 - Article
C2 - 30573724
AN - SCOPUS:85058910020
VL - 19
SP - 1519
EP - 1521
JO - American Journal of Case Reports
JF - American Journal of Case Reports
SN - 1941-5923
ER -