Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.
- Focal segmental glomerulosclerosis
- Genetic testing
- Glomerular filtration barrier
- Minimal change disease
- Steroid-resistant nephrotic syndrome
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health