Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology

Samriti Dogra, Frederick J. Kaskel

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalPediatric Nephrology
DOIs
StateAccepted/In press - Oct 26 2016

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Keywords

  • Focal segmental glomerulosclerosis
  • Genetic testing
  • Glomerular filtration barrier
  • Minimal change disease
  • Podocyte
  • Steroid-resistant nephrotic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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