Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology

Samriti Dogra; Frederick Kaskel

doi:10.1007/s00467-016-3459-5

Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology

Samriti Dogra, Frederick Kaskel

Pediatrics

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.

Original language	English (US)
Pages (from-to)	965-974
Number of pages	10
Journal	Pediatric Nephrology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1007/s00467-016-3459-5
State	Published - Jun 1 2017

Keywords

Focal segmental glomerulosclerosis
Genetic testing
Glomerular filtration barrier
Minimal change disease
Podocyte
Steroid-resistant nephrotic syndrome

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/s00467-016-3459-5

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title = "Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology",

abstract = "Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.",

keywords = "Focal segmental glomerulosclerosis, Genetic testing, Glomerular filtration barrier, Minimal change disease, Podocyte, Steroid-resistant nephrotic syndrome",

author = "Samriti Dogra and Frederick Kaskel",

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AU - Kaskel, Frederick

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N2 - Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.

AB - Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.

KW - Focal segmental glomerulosclerosis

KW - Genetic testing

KW - Glomerular filtration barrier

KW - Minimal change disease

KW - Podocyte

KW - Steroid-resistant nephrotic syndrome

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Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology

Abstract

Keywords

ASJC Scopus subject areas

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