Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Carl J. Hochhauser, Michael Lewis, Barton A. Kamen, Peter D. Cole

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.

Original languageEnglish (US)
Pages (from-to)967-974
Number of pages8
JournalSupportive Care in Cancer
Volume13
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Child Behavior
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Steroids
Folic Acid Antagonists
Leukemia
Therapeutics
Pediatrics
Psychology

Keywords

  • Behavior
  • Hippocampus
  • Leukemia
  • Methotrexate
  • Mood
  • Steroids

ASJC Scopus subject areas

  • Oncology
  • Nursing(all)

Cite this

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia. / Hochhauser, Carl J.; Lewis, Michael; Kamen, Barton A.; Cole, Peter D.

In: Supportive Care in Cancer, Vol. 13, No. 12, 12.2005, p. 967-974.

Research output: Contribution to journalArticle

Hochhauser, Carl J. ; Lewis, Michael ; Kamen, Barton A. ; Cole, Peter D. / Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia. In: Supportive Care in Cancer. 2005 ; Vol. 13, No. 12. pp. 967-974.
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