Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Carl J. Hochhauser, Michael Lewis, Barton A. Kamen, Peter D. Cole

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.

Original languageEnglish (US)
Pages (from-to)967-974
Number of pages8
JournalSupportive Care in Cancer
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2005

Keywords

  • Behavior
  • Hippocampus
  • Leukemia
  • Methotrexate
  • Mood
  • Steroids

ASJC Scopus subject areas

  • Oncology

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