Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Carl J. Hochhauser; Michael Lewis; Barton A. Kamen; Peter D. Cole

doi:10.1007/s00520-005-0882-8

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Carl J. Hochhauser, Michael Lewis, Barton A. Kamen, Peter D. Cole

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.

Original language	English (US)
Pages (from-to)	967-974
Number of pages	8
Journal	Supportive Care in Cancer
Volume	13
Issue number	12
DOIs	https://doi.org/10.1007/s00520-005-0882-8
State	Published - Dec 2005
Externally published	Yes

Keywords

Behavior
Hippocampus
Leukemia
Methotrexate
Mood
Steroids

ASJC Scopus subject areas

Oncology

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10.1007/s00520-005-0882-8

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title = "Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia",

abstract = "Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.",

keywords = "Behavior, Hippocampus, Leukemia, Methotrexate, Mood, Steroids",

author = "Hochhauser, {Carl J.} and Michael Lewis and Kamen, {Barton A.} and Cole, {Peter D.}",

note = "Funding Information: Acknowledgements PDC is a Damon Runyon-Lilly Clinical Investigator, supported in part by the Damon Runyon Cancer Research Foundation (CI-16-03). BAK is an American Cancer Society Clinical Research Professor.",

year = "2005",

month = dec,

doi = "10.1007/s00520-005-0882-8",

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T1 - Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

AU - Hochhauser, Carl J.

AU - Lewis, Michael

AU - Kamen, Barton A.

AU - Cole, Peter D.

N1 - Funding Information: Acknowledgements PDC is a Damon Runyon-Lilly Clinical Investigator, supported in part by the Damon Runyon Cancer Research Foundation (CI-16-03). BAK is an American Cancer Society Clinical Research Professor.

PY - 2005/12

Y1 - 2005/12

N2 - Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.

AB - Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.

KW - Behavior

KW - Hippocampus

KW - Leukemia

KW - Methotrexate

KW - Mood

KW - Steroids

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M3 - Review article

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SN - 0941-4355

VL - 13

SP - 967

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JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 12

ER -

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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