Stem Cell Regeneration and Repair - Overview

Clement D. Marshall; Alessandra A. Moore; Michael T. Longaker; H. Peter Lorenz

doi:10.1002/9781119282518.ch1

Stem Cell Regeneration and Repair - Overview

Clement D. Marshall, Alessandra A. Moore, Michael T. Longaker, H. Peter Lorenz

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Mammalian skin holds a remarkable capacity to regenerate and repair itself in the face of continuous environmental exposures as well as frequent injuries. During normal skin homeostasis, a complex group of skin stem cells of different origins maintains skin in its healthy state. Following injury, these same stem cells are critical in the wound healing response that repairs the injury and forms new skin. Recent insights into the nature and identities of skin stem cells, gained through elegant and complex experiments, may allow for development of novel therapies that improve skin regeneration and reduce scarring by harnessing the capabilities of native skin stem cells.

Original language	English (US)
Title of host publication	Wound Healing
Subtitle of host publication	Stem Cells Repair and Restorations, Basic and Clinical Aspects
Publisher	Wiley-Blackwell
Pages	1-13
Number of pages	13
ISBN (Electronic)	9781119282518
ISBN (Print)	9781119282488
DOIs	https://doi.org/10.1002/9781119282518.ch1
State	Published - Jan 23 2018
Externally published	Yes

Keywords

Cutaneous injury
Regenerative medicine
Skin
Stem cell
Wound healing

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1002/9781119282518.ch1

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title = "Stem Cell Regeneration and Repair - Overview",

abstract = "Mammalian skin holds a remarkable capacity to regenerate and repair itself in the face of continuous environmental exposures as well as frequent injuries. During normal skin homeostasis, a complex group of skin stem cells of different origins maintains skin in its healthy state. Following injury, these same stem cells are critical in the wound healing response that repairs the injury and forms new skin. Recent insights into the nature and identities of skin stem cells, gained through elegant and complex experiments, may allow for development of novel therapies that improve skin regeneration and reduce scarring by harnessing the capabilities of native skin stem cells.",

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AU - Marshall, Clement D.

AU - Moore, Alessandra A.

AU - Longaker, Michael T.

AU - Lorenz, H. Peter

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Y1 - 2018/1/23

N2 - Mammalian skin holds a remarkable capacity to regenerate and repair itself in the face of continuous environmental exposures as well as frequent injuries. During normal skin homeostasis, a complex group of skin stem cells of different origins maintains skin in its healthy state. Following injury, these same stem cells are critical in the wound healing response that repairs the injury and forms new skin. Recent insights into the nature and identities of skin stem cells, gained through elegant and complex experiments, may allow for development of novel therapies that improve skin regeneration and reduce scarring by harnessing the capabilities of native skin stem cells.

AB - Mammalian skin holds a remarkable capacity to regenerate and repair itself in the face of continuous environmental exposures as well as frequent injuries. During normal skin homeostasis, a complex group of skin stem cells of different origins maintains skin in its healthy state. Following injury, these same stem cells are critical in the wound healing response that repairs the injury and forms new skin. Recent insights into the nature and identities of skin stem cells, gained through elegant and complex experiments, may allow for development of novel therapies that improve skin regeneration and reduce scarring by harnessing the capabilities of native skin stem cells.

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KW - Regenerative medicine

KW - Skin

KW - Stem cell

KW - Wound healing

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PB - Wiley-Blackwell

ER -

Stem Cell Regeneration and Repair - Overview

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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