Statistical analysis of the distribution of the antibody levels to Mycobacterium bovis antigenes for bovine tuberculosis diagnostics

T. A. Redchuk; N. V. Korotkevich; A. A. Kaberniuk; E. S. Oliinyk; A. Yu Labyntsev; S. I. Romaniuk; D. V. Kolibo; V. A. Busol; S. V. Komisarenko

doi:10.3103/S009545271005004X

Statistical analysis of the distribution of the antibody levels to Mycobacterium bovis antigenes for bovine tuberculosis diagnostics

T. A. Redchuk, N. V. Korotkevich, A. A. Kaberniuk, E. S. Oliinyk, A. Yu Labyntsev, S. I. Romaniuk, D. V. Kolibo, V. A. Busol, S. V. Komisarenko

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The antibody responses to the recombinant analogs of Mycobacterium bovis antigens rMPB63 and rMPB83, as well as to tuberculin PPD, were determined in 96 bovine blood serum specimens. A statistical approach based on the approximation with multiple Gaussian curves with Levenberg-Marquardt algorithm was proposed for analysis of the distribution of antibody levels to the studied antigens. The results demonstrate that the recombinant MPB63 and MPB83 antigens along with the traditionally used PPD are appropriate for designing the test kits for diagnosing bovine tuberculosis at a herd level.

Original language	English (US)
Pages (from-to)	280-285
Number of pages	6
Journal	Cytology and Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.3103/S009545271005004X
State	Published - Oct 2010
Externally published	Yes

ASJC Scopus subject areas

Genetics
Agricultural and Biological Sciences (miscellaneous)
Cell Biology

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10.3103/S009545271005004X

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Redchuk, T. A., Korotkevich, N. V., Kaberniuk, A. A., Oliinyk, E. S., Labyntsev, A. Y., Romaniuk, S. I., Kolibo, D. V., Busol, V. A., & Komisarenko, S. V. (2010). Statistical analysis of the distribution of the antibody levels to Mycobacterium bovis antigenes for bovine tuberculosis diagnostics. Cytology and Genetics, 44(5), 280-285. https://doi.org/10.3103/S009545271005004X

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abstract = "The antibody responses to the recombinant analogs of Mycobacterium bovis antigens rMPB63 and rMPB83, as well as to tuberculin PPD, were determined in 96 bovine blood serum specimens. A statistical approach based on the approximation with multiple Gaussian curves with Levenberg-Marquardt algorithm was proposed for analysis of the distribution of antibody levels to the studied antigens. The results demonstrate that the recombinant MPB63 and MPB83 antigens along with the traditionally used PPD are appropriate for designing the test kits for diagnosing bovine tuberculosis at a herd level.",

author = "Redchuk, {T. A.} and Korotkevich, {N. V.} and Kaberniuk, {A. A.} and Oliinyk, {E. S.} and Labyntsev, {A. Yu} and Romaniuk, {S. I.} and Kolibo, {D. V.} and Busol, {V. A.} and Komisarenko, {S. V.}",

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doi = "10.3103/S009545271005004X",

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AU - Redchuk, T. A.

AU - Korotkevich, N. V.

AU - Kaberniuk, A. A.

AU - Oliinyk, E. S.

AU - Labyntsev, A. Yu

AU - Romaniuk, S. I.

AU - Kolibo, D. V.

AU - Busol, V. A.

AU - Komisarenko, S. V.

PY - 2010/10

Y1 - 2010/10

N2 - The antibody responses to the recombinant analogs of Mycobacterium bovis antigens rMPB63 and rMPB83, as well as to tuberculin PPD, were determined in 96 bovine blood serum specimens. A statistical approach based on the approximation with multiple Gaussian curves with Levenberg-Marquardt algorithm was proposed for analysis of the distribution of antibody levels to the studied antigens. The results demonstrate that the recombinant MPB63 and MPB83 antigens along with the traditionally used PPD are appropriate for designing the test kits for diagnosing bovine tuberculosis at a herd level.

AB - The antibody responses to the recombinant analogs of Mycobacterium bovis antigens rMPB63 and rMPB83, as well as to tuberculin PPD, were determined in 96 bovine blood serum specimens. A statistical approach based on the approximation with multiple Gaussian curves with Levenberg-Marquardt algorithm was proposed for analysis of the distribution of antibody levels to the studied antigens. The results demonstrate that the recombinant MPB63 and MPB83 antigens along with the traditionally used PPD are appropriate for designing the test kits for diagnosing bovine tuberculosis at a herd level.

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Statistical analysis of the distribution of the antibody levels to Mycobacterium bovis antigenes for bovine tuberculosis diagnostics

Abstract

ASJC Scopus subject areas

UN SDGs

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