Statin use and hospitalization for sepsis in patients with chronic kidney disease

Rajesh Gupta, Laura C. Plantinga, Nancy E. Fink, Michal L. Melamed, Josef Coresh, Caroline S. Fox, Nathan W. Levin, Neil R. Powe

Research output: Contribution to journalArticle

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Abstract

Context: Patients with chronic kidney disease are at high risk for sepsis and sepsisrelated mortality. Objective: To assess whether statin use is associated with a reduction in hospitalizations for sepsis in dialysis patients. Design, Setting, and Patients: National prospective cohort study that enrolled 1041 incident dialysis patients at 81 US not-for-profit outpatient dialysis clinics from October 1995 to June 1998, with follow-up to January 2005. Statin use was determined by medical record review. Rates of hospitalization for sepsis between statin users and control patients were compared using multivariate regression models, with adjustment for potential confounders in the overall cohort and in a subcohort in which control patients were matched to statin users according to their likelihood (propensity) to have been prescribed a statin. Main Outcome Measure: Hospitalizations for sepsis were determined through hospital records from the United States Renal Data System (mean follow-up, 3.4 years). Results: There were 303 hospitalizations for sepsis. Rates of sepsis-related hospitalizations were significantly lower in patients receiving statins (crude incidence rate, 41/ 1000 patient-years) than in those not receiving statins (crude incidence rate, 110/ 1000 patient-years) (P<.001). With adjustment for demographics and dialysis modality, statin users were substantially less likely to be subsequently hospitalized for sepsis (incidence rate ratio, 0.41; 95% confidence interval [CI], 0.25-0.68). Further adjustment for comorbidities and laboratory values continued to show this protective association (incidence rate ratio, 0.38; 95% CI, 0.21-0.67). In the propensity-matched subcohort, statin use was even more protective (incidence rate ratio, 0.24; 95% CI, 0.11-0.49). Conclusions: Use of statins was strongly and independently associated with a reduction in the risk of hospitalization for sepsis in patients who had chronic kidney disease and were receiving dialysis. Randomized trials of statins in patients with chronic kidney disease should examine the prevention of sepsis as a potentially important benefit.

Original languageEnglish (US)
Pages (from-to)1455-1464
Number of pages10
JournalJournal of the American Medical Association
Volume297
Issue number13
DOIs
StatePublished - Apr 4 2007

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Chronic Renal Insufficiency
Sepsis
Hospitalization
Dialysis
Incidence
Confidence Intervals
Hospital Records
Risk Reduction Behavior
Ambulatory Care Facilities
Information Systems
Medical Records
Comorbidity
Cohort Studies
Demography
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Statin use and hospitalization for sepsis in patients with chronic kidney disease. / Gupta, Rajesh; Plantinga, Laura C.; Fink, Nancy E.; Melamed, Michal L.; Coresh, Josef; Fox, Caroline S.; Levin, Nathan W.; Powe, Neil R.

In: Journal of the American Medical Association, Vol. 297, No. 13, 04.04.2007, p. 1455-1464.

Research output: Contribution to journalArticle

Gupta, R, Plantinga, LC, Fink, NE, Melamed, ML, Coresh, J, Fox, CS, Levin, NW & Powe, NR 2007, 'Statin use and hospitalization for sepsis in patients with chronic kidney disease', Journal of the American Medical Association, vol. 297, no. 13, pp. 1455-1464. https://doi.org/10.1001/jama.297.13.1455
Gupta, Rajesh ; Plantinga, Laura C. ; Fink, Nancy E. ; Melamed, Michal L. ; Coresh, Josef ; Fox, Caroline S. ; Levin, Nathan W. ; Powe, Neil R. / Statin use and hospitalization for sepsis in patients with chronic kidney disease. In: Journal of the American Medical Association. 2007 ; Vol. 297, No. 13. pp. 1455-1464.
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abstract = "Context: Patients with chronic kidney disease are at high risk for sepsis and sepsisrelated mortality. Objective: To assess whether statin use is associated with a reduction in hospitalizations for sepsis in dialysis patients. Design, Setting, and Patients: National prospective cohort study that enrolled 1041 incident dialysis patients at 81 US not-for-profit outpatient dialysis clinics from October 1995 to June 1998, with follow-up to January 2005. Statin use was determined by medical record review. Rates of hospitalization for sepsis between statin users and control patients were compared using multivariate regression models, with adjustment for potential confounders in the overall cohort and in a subcohort in which control patients were matched to statin users according to their likelihood (propensity) to have been prescribed a statin. Main Outcome Measure: Hospitalizations for sepsis were determined through hospital records from the United States Renal Data System (mean follow-up, 3.4 years). Results: There were 303 hospitalizations for sepsis. Rates of sepsis-related hospitalizations were significantly lower in patients receiving statins (crude incidence rate, 41/ 1000 patient-years) than in those not receiving statins (crude incidence rate, 110/ 1000 patient-years) (P<.001). With adjustment for demographics and dialysis modality, statin users were substantially less likely to be subsequently hospitalized for sepsis (incidence rate ratio, 0.41; 95{\%} confidence interval [CI], 0.25-0.68). Further adjustment for comorbidities and laboratory values continued to show this protective association (incidence rate ratio, 0.38; 95{\%} CI, 0.21-0.67). In the propensity-matched subcohort, statin use was even more protective (incidence rate ratio, 0.24; 95{\%} CI, 0.11-0.49). Conclusions: Use of statins was strongly and independently associated with a reduction in the risk of hospitalization for sepsis in patients who had chronic kidney disease and were receiving dialysis. Randomized trials of statins in patients with chronic kidney disease should examine the prevention of sepsis as a potentially important benefit.",
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AU - Fink, Nancy E.

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AU - Coresh, Josef

AU - Fox, Caroline S.

AU - Levin, Nathan W.

AU - Powe, Neil R.

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