STAT3 pathway as a molecular target for resveratrol in breast cancer treatment

Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Signal transducer and activator of transcription 3 (STAT3) induces breast cancer malignancy. Recent clinical and preclinical studies have demonstrated an association between overexpressed and activated STAT3 and breast cancer progression, proliferation, metastasis, and chemoresistance. Resveratrol (RES), a naturally occurring phytoalexin, has demonstrated anti-cancer activity in several disease models. Furthermore, RES has also been shown to regulate the STAT3 signaling cascade via its anti-oxidant and anti-inflammatory effects. In the present review, we describe the STAT3 cascade signaling pathway and address the therapeutic targeting of STAT3 by RES as a tool to mitigate breast cancer.

Original languageEnglish (US)
Article number468
JournalCancer Cell International
Volume21
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Breast cancer
  • Malignancy
  • STAT3

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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