Staphylococcus aureus infection of human endothelial cells potentiates Fc receptor expression

V. Bengualid, V. B. Hatcher, B. Diamond, E. A. Blumberg, F. D. Lowy

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Vasculitis, a recognized complication of staphylococcal-endovascular infections, may result in part, from the expression of FcR by Staphylococcus aureus-infected endothelial cells. FcR were measured using [51]Cr labeled SRBC preincubated with rabbit anti-SRBC IgG. FcR were not detected on uninfected endothelial cells, but were demonstrated on S. aureus infected cells using IgG, but not IgM labeled SRBC. FcR expression was dependent on the initial bacterial density (≥8 x 107 cfu/ml) and on phagocytosis of the staphylococci, but not on new protein synthesis. IgG labeled SRBC binding was blocked by aggregated IgG but not IgM. SRBC coated with the F(ab')2 portion of IgG did not bind, thus confirming that FcR were specifically involved in this interaction. FcR are expressed r S. aureus invasion of human endothelial cells and may contribute to the vasculitis which often accompanies S. aureus-endovascular infections.

Original languageEnglish (US)
Pages (from-to)4279-4283
Number of pages5
JournalJournal of Immunology
Volume145
Issue number12
StatePublished - 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Bengualid, V., Hatcher, V. B., Diamond, B., Blumberg, E. A., & Lowy, F. D. (1990). Staphylococcus aureus infection of human endothelial cells potentiates Fc receptor expression. Journal of Immunology, 145(12), 4279-4283.