Stability of Polyadenylated RNA in Differentiating Myogenic Cells

Robert H. SINGER; Gania KESSLER‐ICEKSON

doi:10.1111/j.1432-1033.1978.tb12461.x

Stability of Polyadenylated RNA in Differentiating Myogenic Cells

Robert H. SINGER, Gania KESSLER‐ICEKSON

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Three independent methods of measurement showed that cytoplasmic polyadenylated RNA from the differentiating myogenic cell line L8 consists of two main populations with regard to stability, one with a half‐life of less than 4 h and the other with a half‐life of 17–54 h. Similar results were obtained in the presence and absence of actinomycin D. During the fusion of mononucleated myoblasts into multinucleated fibers, there was an increase in both the steady‐state pool of the more stable polyadenylated RNA and the proportion of stable polyadenylated RNA synthesized in pulse labelling.

Original language	English (US)
Pages (from-to)	395-402
Number of pages	8
Journal	European Journal of Biochemistry
Volume	88
Issue number	2
DOIs	https://doi.org/10.1111/j.1432-1033.1978.tb12461.x
State	Published - Aug 1978
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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AB - Three independent methods of measurement showed that cytoplasmic polyadenylated RNA from the differentiating myogenic cell line L8 consists of two main populations with regard to stability, one with a half‐life of less than 4 h and the other with a half‐life of 17–54 h. Similar results were obtained in the presence and absence of actinomycin D. During the fusion of mononucleated myoblasts into multinucleated fibers, there was an increase in both the steady‐state pool of the more stable polyadenylated RNA and the proportion of stable polyadenylated RNA synthesized in pulse labelling.

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