Squamous cervical lesions in women with human immunodeficiency virus

Long-term follow-up

L. Stewart Massad, Eric C. Seaberg, Rodney L. Wright, Teresa Darragh, Yi Chun Lee, Christine Colie, Robert D. Burk, Howard Strickler, D. Heather Watts

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE:: To estimate the frequency of and trends in abnormal Pap test results in women with human immunodeficiency virus (HIV) and HIV-uninfected women. METHODS:: In a cohort study of HIV-infected and uninfected women, Pap tests were obtained every 6 months. Results of atypical squamous cells of undetermined significance (ASC-US) or worse were considered abnormal. RESULTS:: Over a median of 8.4 years, 23,843 Pap tests were obtained from 1,931 HIV-positive women with 6,828 Pap tests from 533 HIV-negative women (13 women seroconverted during the study). Among women with HIV, Pap test results were ASC-US in 4,462 (19%), low-grade squamous intraepithelial lesion (LSIL) in 3,199 (13%), high-grade squamous intraepithelial lesion (HSIL) in 267 (1%), and cancer in 11 (0.05%). The incidence of abnormal Pap test results was 179 in 1,000 person-years for HIV-positive and 75 in 1,000 person-years for HIV-negative women (incidence rate ratio 2.4, 95% confidence interval 2.0-2.8). The incidence of HSIL or cancer was 4.4 in 1,000 person-years for HIV-positive and 1.3 in 1,000 person-years for HIV-negative women (incidence rate ratio 3.4, 95% confidence interval 1.2-9.5). CONCLUSION:: Among women with HIV in a cervical cancer prevention program, Pap test abnormalities are common, but high-grade abnormalities are infrequent.

Original languageEnglish (US)
Pages (from-to)1388-1393
Number of pages6
JournalObstetrics and Gynecology
Volume111
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Papanicolaou Test
HIV
Incidence
Confidence Intervals
Uterine Cervical Neoplasms
HIV-1
Neoplasms
Cohort Studies

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Squamous cervical lesions in women with human immunodeficiency virus : Long-term follow-up. / Massad, L. Stewart; Seaberg, Eric C.; Wright, Rodney L.; Darragh, Teresa; Lee, Yi Chun; Colie, Christine; Burk, Robert D.; Strickler, Howard; Watts, D. Heather.

In: Obstetrics and Gynecology, Vol. 111, No. 6, 06.2008, p. 1388-1393.

Research output: Contribution to journalArticle

Massad, L. Stewart ; Seaberg, Eric C. ; Wright, Rodney L. ; Darragh, Teresa ; Lee, Yi Chun ; Colie, Christine ; Burk, Robert D. ; Strickler, Howard ; Watts, D. Heather. / Squamous cervical lesions in women with human immunodeficiency virus : Long-term follow-up. In: Obstetrics and Gynecology. 2008 ; Vol. 111, No. 6. pp. 1388-1393.
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abstract = "OBJECTIVE:: To estimate the frequency of and trends in abnormal Pap test results in women with human immunodeficiency virus (HIV) and HIV-uninfected women. METHODS:: In a cohort study of HIV-infected and uninfected women, Pap tests were obtained every 6 months. Results of atypical squamous cells of undetermined significance (ASC-US) or worse were considered abnormal. RESULTS:: Over a median of 8.4 years, 23,843 Pap tests were obtained from 1,931 HIV-positive women with 6,828 Pap tests from 533 HIV-negative women (13 women seroconverted during the study). Among women with HIV, Pap test results were ASC-US in 4,462 (19{\%}), low-grade squamous intraepithelial lesion (LSIL) in 3,199 (13{\%}), high-grade squamous intraepithelial lesion (HSIL) in 267 (1{\%}), and cancer in 11 (0.05{\%}). The incidence of abnormal Pap test results was 179 in 1,000 person-years for HIV-positive and 75 in 1,000 person-years for HIV-negative women (incidence rate ratio 2.4, 95{\%} confidence interval 2.0-2.8). The incidence of HSIL or cancer was 4.4 in 1,000 person-years for HIV-positive and 1.3 in 1,000 person-years for HIV-negative women (incidence rate ratio 3.4, 95{\%} confidence interval 1.2-9.5). CONCLUSION:: Among women with HIV in a cervical cancer prevention program, Pap test abnormalities are common, but high-grade abnormalities are infrequent.",
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AU - Massad, L. Stewart

AU - Seaberg, Eric C.

AU - Wright, Rodney L.

AU - Darragh, Teresa

AU - Lee, Yi Chun

AU - Colie, Christine

AU - Burk, Robert D.

AU - Strickler, Howard

AU - Watts, D. Heather

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N2 - OBJECTIVE:: To estimate the frequency of and trends in abnormal Pap test results in women with human immunodeficiency virus (HIV) and HIV-uninfected women. METHODS:: In a cohort study of HIV-infected and uninfected women, Pap tests were obtained every 6 months. Results of atypical squamous cells of undetermined significance (ASC-US) or worse were considered abnormal. RESULTS:: Over a median of 8.4 years, 23,843 Pap tests were obtained from 1,931 HIV-positive women with 6,828 Pap tests from 533 HIV-negative women (13 women seroconverted during the study). Among women with HIV, Pap test results were ASC-US in 4,462 (19%), low-grade squamous intraepithelial lesion (LSIL) in 3,199 (13%), high-grade squamous intraepithelial lesion (HSIL) in 267 (1%), and cancer in 11 (0.05%). The incidence of abnormal Pap test results was 179 in 1,000 person-years for HIV-positive and 75 in 1,000 person-years for HIV-negative women (incidence rate ratio 2.4, 95% confidence interval 2.0-2.8). The incidence of HSIL or cancer was 4.4 in 1,000 person-years for HIV-positive and 1.3 in 1,000 person-years for HIV-negative women (incidence rate ratio 3.4, 95% confidence interval 1.2-9.5). CONCLUSION:: Among women with HIV in a cervical cancer prevention program, Pap test abnormalities are common, but high-grade abnormalities are infrequent.

AB - OBJECTIVE:: To estimate the frequency of and trends in abnormal Pap test results in women with human immunodeficiency virus (HIV) and HIV-uninfected women. METHODS:: In a cohort study of HIV-infected and uninfected women, Pap tests were obtained every 6 months. Results of atypical squamous cells of undetermined significance (ASC-US) or worse were considered abnormal. RESULTS:: Over a median of 8.4 years, 23,843 Pap tests were obtained from 1,931 HIV-positive women with 6,828 Pap tests from 533 HIV-negative women (13 women seroconverted during the study). Among women with HIV, Pap test results were ASC-US in 4,462 (19%), low-grade squamous intraepithelial lesion (LSIL) in 3,199 (13%), high-grade squamous intraepithelial lesion (HSIL) in 267 (1%), and cancer in 11 (0.05%). The incidence of abnormal Pap test results was 179 in 1,000 person-years for HIV-positive and 75 in 1,000 person-years for HIV-negative women (incidence rate ratio 2.4, 95% confidence interval 2.0-2.8). The incidence of HSIL or cancer was 4.4 in 1,000 person-years for HIV-positive and 1.3 in 1,000 person-years for HIV-negative women (incidence rate ratio 3.4, 95% confidence interval 1.2-9.5). CONCLUSION:: Among women with HIV in a cervical cancer prevention program, Pap test abnormalities are common, but high-grade abnormalities are infrequent.

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